Pseudohypoparathyroidism type Ia (PHP-Ia) is characterized by multihormone resistance and an Albright hereditary osteodystrophy (AHO) phenotype. It is caused by heterozygous mutations in GNAS gene. Clinical and biochemical findings of a female PHP-Ia patient were evaluated from age of diagnosis (6.5 years) to 14.5 years of age. The patient had short stature, brachydactyly, and subcutaneous hete...

We provide a number of practical techniques and algorithms for exploiting randomness vulnerabilities in PHP applications.We focus on the predictability of password reset tokens and demonstrate how an attacker can take over user accounts in a web application via predicting or algorithmically derandomizing the PHP core randomness generators. While our techniques are designed for the PHP language,...

PURPOSE Type I pseudohypoparathyroidism (PHP-I) can be subclassified into Ia and Ib, depending on the presence or absence of Albright's hereditary osteodystrophy's phenotype, diminished α-subunit of the stimulatory G protein (G(s)α) activity and multihormonal resistance. Whereas PHP-Ia is mainly associated with heterozygous inactivating mutations in G(s)α-coding exons of GNAS, PHP-Ib is caused ...

Public health physicians (PHPs) are certified physicians who are serving in a public health center or subcenter in a rural village, instead of serving in the military. However, the PHP program has recently become the subject of a profound debate, over 30 years after its adoption. In this study, we attempted to ascertain physicians' perspectives on the PHP program, including: whether the PHP pol...

Although the molecular basis of pseudohypoparathyroidism type 1b (PHP type 1b) remains unknown, a defect in imprinting at the GNAS1 locus has been suggested by the consistent finding of paternal-specific patterns of DNA methylation on maternally inherited GNAS1 alleles. To characterize the relationship between the genetic and epigenetic defects in PHP type 1b, we analyzed allelic expression and...

We provide a number of practical techniques and algorithms for exploiting randomness vulnerabilities in PHP applications.We focus on the predictability of password reset tokens and demonstrate how an attacker can take over user accounts in a web application via predicting or algorithmically derandomizing the PHP core randomness generators. While our techniques are designed for the PHP language,...

During code development it is crucial to get fast feedback about the correctness of our code. Various hints are given by compiler through warnings and error messages that are displayed in the IDE, e.g. Eclipse. Unfortunately, this covers only the general host-language, in which we write the code. Often we need to use another language to communicate with a specific application domain: e.g. SQL f...

Studies were carried out to compare the effects of parathyroid extract (PTE) on serum and urinary calcium (Ca) and phosphorus (P), serum 25-hydroxyvitamin D (25-OHD), serum 24,25-dihydroxyvitamin D (24,25(OH)2D), serum 1 alpha,25-dihydroxyvitamin D (1 alpha,25(OH)2D), and urinary cyclic AMP in two normal subjects, two patients with hypoparathyroidism (HP) and six patients with pseudohypoparathy...