In the summer of 1938 an outbreak of encephalomyelitis in man in the vicinity of Massachusetts was proved to be due to the virus of equine encephalomyetitis, Eastern strain (1). An epidemic of encephalomyelitis in horses had appeared a month before and continued during the human outbreak (2). I t was thought, although not proved, that the virus was transmitted by mosquito vectors (3). The age d...

The cytolytic animal virus equine herpesvirus type 1 (EHV-1) was evaluated for its oncolytic potential against five human glioblastoma cell lines. EHV-1 productively infected four of these cell lines, and the degree of infection was positively correlated with glioma cell death. No human major histocompatibility complex class 1 (MHC-I) was detected in the resistant glioma line, while infection o...

Microquantitative complement fixation was used to de tect antibody to AG-4, a tumor-associated herpesvirus type 2-induced antigen, in sera from Japanese patients with cer vical neoplasia. The prevalence of antibody to AG-4 in cervi cal cancer patients is 47% as compared to 7% in control women. That AG-4 antibody is less prevalent in Japanese than in American cancer patients reflects the frequen...

A total of 51 sera from a migratory population of Burchell's zebras (Equus burchelli) were collected in the Serengeti National Park (Tanzania) between 1999 and 2001 to assess levels of exposure to equine herpesvirus types 1, 2, 4, 9 (EHV-1, -2, -4, -9), EHV-1 zebra isolate T965, and equine arteritis virus (EAV). Using virus-specific neutralizing antibody tests, seroprevalence was high for EHV-9...

BACKGROUND A large multistate outbreak of equine herpesvirus myeloencephalopathy (EHM) occurred in May 2011 among horses that participated in a competitive event. OBJECTIVE To identify EHM risk factors among horses with a common exposure venue. ANIMALS A total of 123 horses: 19 horses with EHM, 14 equine herpesvirus-1 cases with no reported neurologic signs, and 90 control horses. METHODS...

Reviewers Gözde Bozdağı Akar Aydın Alatan Cüneyt Bazlamaçcı Elif Uysal Bıyıkoğlu Çağatay Candan Özlem Aydın Çivi Yeşim Serinağaoğlu Doğrusöz Murat Eyüboğlu Nevzat Güneri Gençer Sencer Koç Fatih Koçer Mustafa Kuzuoğlu Kemal Leblebicioğlu Umut Orguner Afşar Saranlı Gönül Turhan Sayan Ece Güran Schmidt Mete Severcan Ali Özgür Yılmaz Session Chairs/Evaluators Gözde Bozdağı Akar Aydın Alatan Lale Al...

The effect of in vitro and in vivo serial virus passage on the genetic stability of equine herpesvirus 1 (EHV-1) was investigated by restriction endonuclease analysis of the viral DNA. DNAs of EHV-1 isolates at different passage levels in cultured cells or in Syrian hamsters were compared by electrophoresis of the DNA cleavage fragments produced by restriction endonuclease digestion. No changes...

The endotheliotropism of equine herpesvirus-1 (EHV-1) leads to encephalomyelitis secondary to vasculitis and thrombosis in the infected horse central nervous system (CNS). To identify the host factors involved in EHV-1 infection of CNS endothelial cells, we performed functional cloning using an equine brain microvascular endothelial cell cDNA library. Exogenous expression of equine major histoc...