Alzheimer hastalığı (AH) öncelikli olarak yaşlı popülasyonda görülen, klinik bellek ve bilişsel bozukluklar ile karakterize, ilerleyici nörodejeneratif bir hastalıktır. 
 Hastalığın etiyolojisinin henüz tam belirlenememiş olması, hasta popülasyonunun yıllar geçtikçe artması, radikal tedavinin olmayışı, tedavi bakım maliyetinin oldukça yüksek hastaların yaşam kalitesini düşürmesi gibi sebep...

Molecular modeling analysis of charge density and heat of fornation by PM3 method as well as C, H NMR and 2D-NMR measurements of histidine (substrate) and some of its derivatives as histidine decarboxylase inhibitors were performed. It was established that the atom, usually nitrogen, which forms internal aldimine with pyridoxal5 -phosphate (PLP), (coenzyme), has negative and almost equal ...

A general synthetic route to the synthesis of imidazoles has been developed using nano SbCl5/SiO2 under solvent-free conditions. The multi-component reactions of aldehydes, benzil and ammonium acetate were carried out to afford some trisubstituted imidazole derivatives. This method provides several advantages like simple work-up, environmentally benign, and shorter reaction times along wi...

We report a new type of fast photochromic imidazole dimer, pentaarylbiimidazole (PABI), which shows a few μs fast photochromism with high fatigue resistance against light irradiation. PABI has an unusual spiroconjugated imidazoisoindole skeleton and its derivatives can be prepared by simple synthetic procedures.

The CO-specific heme-based sensor CooA regulates the ability of Rhodospirillum rubrum to grow on CO as an energy source. Only CO triggers the conformational change of CooA essential for the protein to function as a transcriptional activator. A structurally informed mutagenesis, followed by an in vivo screening method, allowed the isolation of a series of novel CooA variants that show very subst...

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction c...

A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds <str...

A three-component reaction of beta-nitrostyrene, arylmethylidenemalononitrile and malononitrile catalyzed by imidazole produced the corresponding polysubstituted cyclohexene derivatives in moderate to good yields under mild conditions. A further improvement of this three-component reaction has also been achieved by starting from a commercially available aromatic aldehyde, nitromethane and malon...

A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a simple and efficient way to synthesize 2,4-disubstituted 5-nitroimidazole derivatives with antibac...