T hree randomized, controlled trials have demonstrated substantial improvements in overall survival for patients with advanced ovarian cancer who received chemotherapy via the intraperito-neal (IP) route — injected directly into the peritoneal cavity — compared with those who received it intravenously. Moreover, the National Cancer Institute has recommended that intraperitoneal treatment to be ...

This study aimed to investigate the effects of the administration of butanolic residue (BR) of Pfaffia paniculata by intraperitoneal route to Ehrlich ascitis tumor bearing mice. Initially, a toxicity study of P. paniculata BR was performed in which doses of 12.5; 25 and 50mg/Kg were administered by intraperitoneal injection for seven days to Swiss mice. The treatment did not show toxicity. Then...

Passive oral immunization with O-antiserum was found to protect guinea pigs against fatal enteric cholera. The number of vibrios recoverable from the intestines of infected animals was not noticeably reduced by active and oral passive immunization. Passive immunization by the intraperitoneal route was not protective even though high titers of circulating antibody were obtained shortly after inj...

Oral administration of BL-3849A to adult mice resulted in peak serum interferon titers of 4,000 units from 15 to 30 h after administration, with detectable levels persisting until 48 h. After intraperitoneal (i.p.) inoculation, peak serum interferon titers of 1,000 to 3,000 units were noted between 9 and 18 h. Multiple injections of the inducer by either route resulted in a marked decrease in t...

The observations of homogeneous, intracellular inclusion bodies in association with Rickettsia orientalis were made during an investigation of scrub typhus in Imphal in 1945 and were submitted in reports to GHQ(I). Twenty-five strains of R orientalis were isolated from different sources. Similar observations have been made by Giroud and Panthier (1942) and Begg and others (1944) in association ...

Using a quantitative technic for depositing a definite number of carcinoma or sarcoma cells into the anterior chamber of the mouse eye, without leakage as proven by complete reten tion of Trypan blue dye, this route generally required a 100to 1,000-fold lower dose of cells to produce tumors in 100% of animals, as compared to the intramuscular, intravenous, and intraperitoneal routes of inoculat...

Delivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi's sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do inhibit the morphological differentiation ...

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

Using a quantitative technic for depositing a definite number of carcinoma or sarcoma cells into the anterior chamber of the mouse eye, without leakage as proven by complete reten tion of Trypan blue dye, this route generally required a 100to 1,000-fold lower dose of cells to produce tumors in 100% of animals, as compared to the intramuscular, intravenous, and intraperitoneal routes of inoculat...

A protein extract isolated from the seeds of Abrus preca torius L. is shown to exhibit antitumor activity on Yoshida sarcoma (solid and ascites forms) in rats and a fibrosarcoma in mice. The intraperitoneal route of administration is more ef fective than subcutaneous injections. The extract has a direct cytotoxic effect on the tumor cells. Vacuolation and disrup tion of cytoplasm accompanied by...