Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel was determined by electron crystallography at resolutions of 7.5 angstroms in the membrane plane and 21 angstroms in the vertical direction. The dodecameric channel was formed by the end-to-end docking of two hexamers, each of which display...

Horizontally stratified flows can be seen in a wide variety of micro-scale engineering problems. Recent studies have shown that diffusion at the interface between two liquids leads to lateral flow, causing fluid rotate around central axis channel. This flow has potential disrupt intended mechanism device or exploited for new designs. The present investigation presents numerical and experimental...

Phosphorylation at unspecified sites is known to regulate the life cycle (assembly, gating, and turnover) of the gap junction protein, Cx43. In this paper, we show that Cx43 is phosphorylated on S365 in cultured cells and heart tissue. Nuclear magnetic resonance structural studies of the C-terminal region of Cx43 with an S365D mutation indicate that it forms a different stable conformation than...

The present work proposes towards flow pattern prediction in a liquidliquid microchannel flow through a circular channel. Mass transfer in a microchannel mainly depends on the flow regime inside the channel. The liquid-liquid two phase flow regime in a microchannel depends on the flow velocity and the junction characteristics. Hence, the prediction of patterns has a superior role for the charac...

The High Electron Mobility Transistor (HEMT) is a small geometry hetero-junction device that exploits the high electron mobility in an undoped region to achieve high speed operation. Hetero-junction is used to create a narrow undoped electron well which forms the channel for current flow. The electron mobility in the channel is found to be maximum due to the adequate presence of Indium quantity...

ow do you construct a channel between cells ? The first step in answering this question was to isolate the components of one type of channel—the gap junction. H Daniel Goodenough had been pursuing gap junction proteins since his days as a graduate student in the mid-1960s with Jean-Paul Revel, who helped discover the structures (Revel and Karnovsky, 1967; see “Defining gap junctions” JCB 169:37...

We propose a grounded ontological theory of channel networks to categorize features, like junctions, in road network databases. The theory is grounded, because its primitives can be given an unambiguous interpretation into directly observable qualities of physical road networks, like supported movements and their medium, connectedness of such media, and turnoff restrictions. The theory provides...

Gap junction channels provide the basis for intercellular communication and play an important physiological role in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone, endothelial function and myoendothelial interaction as well as for metabolic interchange between the cells. Thus, pharmacological influence on these channels might help to elucidat...

tuberculous spondylitis is not an uncommon disease of the spine. near one percent of all cases of spinal tuberculosis (tb) involves craniocervical junction. hypoglossal nerve palsy is not an uncommon neurological finding, but isolated involvement of the hypoglossal nerve is rare and limited to case reports or small case series. here, we report a case of craniocervical junction tuberculosis pres...

background: recent researches have led to find strategies to prevent relapse and to improve survival for gastric cancer patients, including preoperative neo-adjuvant approaches. however, the efficacy of some neo-adjuvant regimens including 5-fluorouracil, cisplatin, and docetaxel have been less investigated. the present study evaluated the outcome and mid-term survival of patients with gastric ...