نتایج جستجو برای: copd mice model
تعداد نتایج: 2448346 فیلتر نتایج به سال:
Chronic obstructive pulmonary disease(COPD) is characterized by enhanced chronic inflammation in the airways, lung parenchyma, and circulation. We investigated whether SUV39H1, a histone methyltransferase, is causatively implicated in the abnormal inflammation observed in COPD. The SUV39H1 and H3K9me3 levels were reduced in peripheral blood mononuclear cells(PBMCs), primary human small airway e...
background: diagnostic models are frequently used to assess the role of risk factors on disease complications, and therefore to avoid them. missing data is an issue that challenges the model making. the aim of this study was to develop a diagnostic model to predict death in hiv/ aids patients when missing data exist. methods: hiv patients (n=1460) referred to voluntary consoling and testing cen...
بیماری انسداد مزمن ریوی copd یکی از علل اصلی مرگ و میر در کشورهای در حال توسعه و توسعه یافته است که میزان مرگ و میر آن در حال افزایش است و تا سال 2020 این بیماری از مقام ششم به سومین علت مرگ در جهان رشد خواهد کرد.همراهی ریسک فاکتور های بیماری های کاردیو واسکولار و اختلال عملکرد بطن چپ در بیماران copd شایع است .این مطالعه به بررسی فراوانی نسبی تروپونین i به عنوان یک بیومارکر اختصاصی قلب در بیمار...
RATIONALE COPD is an inflammatory lung disease largely associated with exposure to cigarette smoke (CS). The mechanism by which CS leads to the pathogenesis of COPD is currently unclear; it is known however that many of the inflammatory mediators present in the COPD lung can be produced via the actions of the transcription factor Nuclear Factor-kappaB (NF-κB) and its upstream signalling kinase,...
Mouse models of chronic obstructive pulmonary disease (COPD) focus on airway inflammation and lung histology, but their use has been hampered by the lack of pulmonary function data in their assessment. Systemic effects such as muscle dysfunction are also poorly modeled in emphysematous mice. We aimed to develop a cigarette-smoke-induced emphysema mouse model in which serial lung function and mu...
Respiratory syncytial viral (RSV) infections are a frequent cause of chronic obstructive pulmonary disease (COPD) exacerbations, which are a major factor in disease progression and mortality. RSV is able to evade antiviral defenses to persist in the lungs of COPD patients. Though RSV infection has been identified in COPD, its contribution to cigarette smoke-induced airway inflammation and lung ...
BACKGROUND COPD is a leading cause of mortality worldwide, and cigarette smoke is a pivotal risk factor. Adenovirus is a common cause of acute exacerbations of COPD and expedites COPD progression. Lung stem/progenitor cells play an important role in the development of COPD, while the relevant mechanism remains elusive. Here, we investigated the number of lung CD31-CD45-Sca-1+ cells and sonic he...
Background: Stress, anxiety, and depression have been reported as very common comorbidities in smokers with chronic obstructive pulmonary disease (COPD). This study was aimed to investigate the effectiveness of smoking cessation on stress, anxiety, and depression in smokers with COPD. Methods: Three block-randomized controlled trial groups with a block size of 6 and 9 including guided self-chan...
Introduction: From human- made pollutants, SO2 has been widely studied. This research aims to estimate the respiratory deaths and COPD related to SO2 pollutant in 2011. Methods: Firstly, the concentration of SO2 pollutant was measured by GRIMM device in 2011 in five stations in Tabriz. The data were processed by Excel software and fed to AIR Q model. Results: The result showed that the ...
1378 INTRODUCTION Chronic obstructive pulmonary disease (COPD) is a global epidemic of major proportions that is predicted to become the third most common cause of death and fifth most frequent cause of chronic disability by 2030 (http://www.who.int/respiratory/copd/ burden/en/). Cigarette smoking is a major risk factor, but several predisposing genetic factors have also been implicated in the ...
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