Although hepatitis C virus (HCV) mainly affects hepatocytes, infection is widespread and involves immunologically privileged sites. Whether lymphoid cells represent further targets of early HCV infection, or whether other cells in the hematopoietic microenvironment may serve as a potential virus reservoir, is still unclear. We studied whether pluripotent hematopoietic CD341 cells support produc...

Although hepatitis C virus (HCV) mainly affects hepatocytes, infection is widespread and involves immunologically privileged sites. Whether lymphoid cells represent further targets of early HCV infection, or whether other cells in the hematopoietic microenvironment may serve as a potential virus reservoir, is still unclear. We studied whether pluripotent hematopoietic CD34(+) cells support prod...

Abstract Background Successful eradication of hepatitis C virus (HCV) has great impact on the prognosis HCV-related complications and associated mortality. The development new direct-acting antiviral drugs (DAAs) revolutionized treatment HCV infection. core antigen (HCVcAg) is a recently developed marker that displayed good correlation with RNA assays. Our main objectives were to correlate betw...

Abstract Background Patients with chronic hemolytic anemias (CHA) are at a high risk for transfusion-transmitted infections. Various studies in Egypt have shown prevalence of hepatitis C virus (HCV) infection 24–37% those patients. Elimination patients CHA would prevent early progression liver disease. In this study, we aimed to assess the efficacy, safety, and tolerability sofosbuvir (SOF) dac...

BACKGROUND Hepatitis C genotype 4 (HCV-4) is considered to be rare outside northern Africa and southern Europe. OBJECTIVES To describe the epidemiological characteristics of patients infected with HCV-4 in Poland. PATIENTS AND METHODS The study group included 290 patients with HCV-related chronic liver disease and intravenous drug users with HCV infection recruited in years 2002-2006 in Pod...

Development of HCV infection is typically followed by chronic hepatitis C (CHC) in most patients, while spontaneous HCV viral clearance (SVC) occurs in only a minority of subjects. Compared with the widespread application of HCV RNA testing by quantitative RT-PCR technique, HCV core antigen detection may be an alternative indicator in the diagnosis of hepatitis C virus infections and in monitor...

conclusions our investigation illustrated that the prevalence of hepatitis c was higher among olp patients compared to the control group. these findings are in line with previous results that reported a hepatitis c prevalence of 0.19% among the general population of mashhad. results of the 134 olp patients only three (2.23 %) had hcv infection where both anti-hcv and hcv-rna were positive. all ...

This study was designed to analyze the feasibility and validity of using Cleavase Fragment Length Polymorphism (CFLP) analysis as an alternative to DNA sequencing for high-throughput screening of hepatitis C virus (HCV) genotypes in a high-volume molecular pathology laboratory setting. By using a 244-bp amplicon from the 5' untranslated region of the HCV genome, 61 clinical samples received for...

BACKGROUND The measurement of anti-HCV antibodies using immunological methods and the confirmation of viral nuclear acid based on molecular methods is important in diagnosis and follow-up of the HCV infection. OBJECTIVES In this study, we aimed to analyse HCV core Antigen positivity among anti-HCV antibody positive sera to determine the significance of testing of HCV core Ag for the laborator...

In hepatitis C Virus (HCV) high-risk groups, HCV-specific T cell responses have been detected in seronegative, aviremic persons who have no evidence of HCV infection. Herein, we investigated functional profiles of HCV-specific T-cell responses in seronegative, aviremic patients of a HCV high-risk group. Seventy seven hemodialysis patients with chronic renal disease were analyzed by IFN-γ ELISpo...