Germander, a plant used in folk medicine, caused an epidemic of cytolytic hepatitis in France. In about half of these patients, a rechallenge caused early recurrence, suggesting an immunoallergic type of hepatitis. Teucrin A (TA) was found responsible for the hepatotoxicity via metabolic activation by CYP3A. In this study, we describe the presence of anti-microsomal epoxide hydrolase (EH) autoa...

A large number of auto-immune diseases are treated with rituximab, an antibody against CD20 that depletes most of the B-cells in the organism. The response to this treatment depends largely on the disease and the type of lymphoid cells involved in the auto-immune process. We recently reported that B-cell depletion in immune thrombocytopenia induced the appearance of pathogenic long-lived plasma...

Introduction: Most B-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. Some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. Molecular techniques can be used as a helpful diagnostic tool in these cases. In this study, we assessed the value of polymerase chain reaction (PCR) t...

ELISA test (titer: 99 and 112 units, respectively). A side effect of efalizumab was suspected, and this medication was discontinued. The search for other auto-immune complications proved negative with absence of antinuclear antibodies, rheumatoid factor, other haematological disturbances and a negative Coombs’ test. The patient was initially treated with highly potent topical steroids (clobetas...

ELISA test (titer: 99 and 112 units, respectively). A side effect of efalizumab was suspected, and this medication was discontinued. The search for other auto-immune complications proved negative with absence of antinuclear antibodies, rheumatoid factor, other haematological disturbances and a negative Coombs’ test. The patient was initially treated with highly potent topical steroids (clobetas...

Background: Inflammatory bowel disease unclassified (IBDU) is considered to be an aberrant immune response with loss of tolerance to many antigens. Objective: This paper tries to address whether there is any value to test for auto-antibodies in such patients. Methods: 60 patients with inflammatory bowel disease unclassified participated in the study. Auto-antibodies to nuclear antigen, intestin...

This numerical study deals with the hazardous ignition of a jet flame in vitiated co-flow. A novel formulation, based on passive scalar variable, will be presented to predict hydrogen auto-ignition events. The model, derived from theoretical analysis Jacobian, correctly describes appearance and absence complex configurations initial thermodynamic mixture conditions. No chemical reaction species...

Autologous peripheral blood stem cell transplantation (auto-PBSCT) after high dose chemotherapy is usually offered to breast cancer patients carrying a high risk of relapse or having chemosensitive metastatic disease. Whether progression free and overall survival of such patients is improved after auto-PBSCT compared to conventional chemotherapy is a matter of debate. Currently available result...

We retrospectively analyzed infectious complications during tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in children and adolescents with high-risk or recurrent solid tumors. A total of 324 patients underwent their first HDCT/auto-SCT between October 2004 and September 2014, and 283 of them proceeded to their second HDCT/auto-SCT (a total of 607 HDCT/au...