Antibody production and clinical efficacy (relative percent survival RPS) were measured in 40±5g rainbow trout after immunization with two types of Streptococcus iniae vaccines consisting of formalin killed cells (FKC) and FKC enriched with the bacterial extracellular products (ECP) administered by intraperitoneal (i.p), immersion and oral routes at 16±1°C for 18 weeks. No sig...

The objective of this study was to determine the bioavailability and disposition of elacridar (GF120918; N-(4-(2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide) in plasma and brain after various routes of administration in the mouse. Elacridar is a potent inhibitor of P-glycoprotein and breast cancer resistance protein and has...

This article has not been copyedited and formatted. The final version may differ from this version. Abstract: The objective of this study was to determine the bioavailability and disposition of elacridar (GF120918) in plasma and brain after various routes of administration in the mouse. Elacridar is a potent inhibitor of P-gp and BCRP and has been used to examine the influence of these efflux t...

Metformin is 1,1-dimethylbiguanide hydrochloride, the first-line therapy for type 2 diabetes. Additionally, several studies focused on role of metformin in antioxidant activities treatment hepatic disorders. The experimentally
 
 -based result valproic acid's liver injury, a front-line medicine epilepsy, attracted lot interest. As result, effect acid-induced redox disturbances rat tis...

The pathogenesis of coxsackie B virus (CVB) infections is generally studied in mice by intraperitoneal (i.p.) injection, whereas the gastrointestinal tract is the natural porte d'entrée in humans. The present study was undertaken to compare systematically the influence of infection route on morbidity and pathology. Swiss Albino mice were infected with CVB3 (Nancy) at different doses (5 x 10(3),...

used to treat hyperlipidemia also exhibit immuno-modulatory properties. What is still unclear and a matter of debate, however, is whether these properties are of benefi t or are deleterious in collagen type II-induced arthritis (CIA). We read with great interest Vandebriel and colleagues' article about the role of statins in the induction of CIA [1]. According to the authors' conclusion, statin...