background: obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. the few approved anti-obesity drugs have poor efficacy and safety profile. thus, there is an urgent need for new anti-obesity agents. according to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. objectives: eva...

background: recent studies have indicated potential of saffron for applying in a wide variety of diseases such as psychiatric and neurologic disorders. the concurrent use of saffron with ssris can lead to reducing the dose of ssris. saffron at a dose of 200 mg may change some hematological and biochemical parameters. objective: the goal of this trial was to assess the safety of concomitant admi...

background: saffron (crocus sativus l.) is a common but very expensive herbal medicine. as an important traditional medicine, it has an outstanding effect in treating irregular and painful menstruation. recently, the over-demand tendency of saffron results in an unusual phenomenon in the medicinal markets. adulterants and saffron-like substitutes are intentionally mixed into medicinal markets a...

background: there is much debate about effects of medicinal plants such as saffron (crocus sativus) on human health. women are highly involved in farming and processing of this plant. this study is aimed at evaluating the saffron impacts on miscarriage rate of female farmers working in saffron fields. methods: this was a prospective case-control study on pregnant female farmers during harvestin...

Since cancer is the most common cause of death in the world population, the possibility that readily available natural substances from plants, vegetables, herbs, and spices may be beneficial in the prevention of cancer warrants closer examination. Saffron in filaments is the dried, dark red stigmata of Crocus sativus L. flowers and it is used as a spice, food colorant, and a drug in medicine. A...

Crocus sativus is a triploid sterile plant with red stigmas belonging to family of Iridaceae, and sub Crocoideae. Crocin, picrocrocin, safranal are three major carotenoid derivatives that responsible for color, taste specific aroma Crocus. Saffron flowers harvested manually used as spice, dye or medicinal applications. The natural propagation rate most geophytes including saffron relatively low...

The application of the Quality by Design (QbD) concept to extracts obtained from Crocus sativus perianth with potential anticancer activity will ensure safety, efficiency, and quality control entire technological process, as well determine critical factors affecting extracts. Potentially points production plant extracts, including cultivation processing materials, extraction choice solvents, we...