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تعداد نتایج: 1079466 فیلتر نتایج به سال:
Background and Aims: Since the produced recombinant proteins by molecular genetics techniques commonly have some limitations in the application, chimeric protein are introduced. Chimeric proteins have found widespread application for the study of protein folding, structure stability, function and immunogenisity. Methods: According to the known Immunomodulatory effect and structure of HSP70 mole...
Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...
Earthquake time history records are required to perform dynamic nonlinear analyses. In order to provide a suitable set of such records, they are scaled to match a target spectrum as introduced in the well-known design codes. Corresponding scaling factors are taken similar in practice however, optimizing them reduces extra-ordinary economic charge for the seismic design. In the present work a ne...
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