Diploid human lymphoblast cells exhibit apparent saturation of mu tation induced by exposure to aflatoxin B,, despite a linear increase in the amount and proportion of the aflatoxin-DNA adducts formed. The saturation is neither a cell cycle phenomenon nor a result of a genetically heterozygous population. Examination of the hiphasic nature of aflatoxinDNA adduct loss in vivoshows initial, rapid...

Controversy exists whether the syllable-final voiceless stops of (S)E Asian languages are reinforced with glottalization in all these languages, i.e. -p -t -k. For example, early laryngoscopic observation of finals in Cantonese, Taiwanese (Fukienese), and Thai found that after vocalization ceases, vocal folds and false vocal folds adduct, and, in some cases, there is engagement of the ary...

In the title 1:1 adduct, C(11)H(10)ClN(3)O(2)·C(18)H(15)OP, the dihedral angle between the pyridine and pyrazole rings is 10.3 (2)°. The two components of the adduct are linked by an O-H⋯O hydrogen bond.

Chemical reactions inside carbon nanotubes can yield unusual outcomes. Molecular dynamics simulations show that within the confined space of carbon nanotubes, the 1,4-exo adduct of a Diels-Alder cycloaddition may be produced instead of the 9,10-adduct, which is favoured in bulk. The likely product is highly dependent on the nanotube radius and reactant size.

A regiospecific bis-adduct of C70 with anthracene was prepared with unusually high yield (68%) by the Diels-Alder reaction in the absence of solvent (melt). The structure of the bis-adduct was an unexpected 12 o'clock isomer, as determined by single crystal X-ray diffraction, thermal gravimetric analysis (TGA) and spectroscopy.

Analysis of 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamide (anandamide) via alkali or alkaline earth metal-adduct high-energy collision-induced dissociation (CID) in fast-atom bombardment (FAB) ionization-mass spectrometry (MS) is described. The CID-MS/MS of the [2-AG+Li](+) or [2-AG+Na](+) ion undergoes charge-remote fragmentation (CRF), which is useful for the determination of t...

Recognition of drugs by immune cells is usually explained by the hapten model, which states that endogenous metabolites bind irreversibly to protein to stimulate immune cells. Synthetic metabolites interact directly with protein-generating antigenic determinants for T cells; however, experimental evidence relating intracellular metabolism in immune cells and the generation of physiologically re...