Huntington's disease is caused by the expansion of CAG repeats coding for a polyglutamine tract in the huntingtin protein. The major pathological feature found in Huntington's disease neurons is the presence of detergent-insoluble ubiquitinated inclusion bodies composed of the huntingtin protein. However, the mechanisms that underlie inclusion body formation, and the precise relationship betwee...

Lead is a ubiquitous environmental and industrial pollutant with a worldwide health problems. A total fifty adult male albino rats were equally divided into five groups to evaluate the toxic effects of lead acetate on liver, kidneys, brain and testes of albino rats, besides assessing the efficacy of myrrh extract in reducing these toxic changes. Group (1) was left without treatment. Each rats i...

A case is described of herpetic hepatitis in a pregnant woman with primary herpetic stomatitis. Intranuclear inclusion bodies and virus particles were found in hepatocytes, and herpes virus was isolated from a liver biopsy and from oral swabs but not from blood. From rising titres of neutralizing and complement-fixing antibody it is concluded that the oral infection was a primary one. Factors p...

background: production of tissue plasminogen activator protein (t-pa) in prokaryotes systems has many problems such as the lack of active protein production, multiple purification steps, and renaturation process which has been shown to be costly and time-consuming. methods: in this study, reteplase which is the nonglycosylated active domain of t-pa was used to transform top10 escherichia coli (...

the neurilemmoma is a benign neoplasm of schwann cell origin. one of the histopathologic subtypes of this tumor is ancient schwannoma which is characterized by degenerative alterations including cystic change, calcification, hemorrhage, and hyalinization. intraosseous schwannomas especially ancient ones are rare tumors. here we present a case of intraosseous ancient schwannoma in the lower jaw ...