BACKGROUND Several genes identified by positional cloning have been associated with asthma and atopy, but few findings have been replicated. Age at onset of asthma has been associated with different phenotypic characteristics, and with variants at chromosome 17q21 identified through genome-wide association. This study examined the associations and age-specific effects on asthma, atopy and bronc...

BACKGROUND The management of asthma attacks by general practitioners in 1992/93 was compared with 1991/92 in relation to recommended guidelines. METHODS The findings from a postal survey of 299 UK general practitioners who managed 2332 patients with an asthma attack in 1992/93 were compared with those from 218 practitioners who managed 1805 attacks in 1991/92. Management by a subgroup of prac...

INTRODUCTION We conducted a cross-sectional population-based survey in New Zealand that collected information on work history, current workplace exposures, and selected health outcomes. We report here the findings on occupational risk factors for asthma symptoms. METHODS A random sample of men and women aged 20-64 years were selected from the New Zealand Electoral Roll and invited to take par...

Asthma is a non communicable obstructive lung disease. It condition in which person's airways become inflamed, narrow, swell, and produce extra mucus, making breathing difficult. After being diagnosed with asthma patients not only suffer from physical symptoms but also mental disorders such as prolonged stress, anxiety disorders, depression, PTSD (Post-traumatic stress disorders), fear panic al...

Background: Asthma is either a chronic respiratory disease or serious global health problem that common in all ages at high rate. It seriously affects not only the physical but also health-related quality of life (HRQoL) patients. Objectives: (1) To determine HRQoL score among asthmatic outpatients Hue University Medicine and Pharmacy Hospital; (2) assess factors associated with Hospital. Subje...

BACKGROUND Nebulized furosemide has been shown to be protective against bronchoconstricting stimuli. METHODS To investigate whether inhaled furosemide would exhibit an additional therapeutic effect in children with acute asthma we performed a double-blind, placebo-controlled study in which patients with acute asthma attack were randomized to receive either nebulized salbutamol (0.15 mg/kg) pl...

OBJECTIVE We analyzed the influence of PM2.5 and house dust mite antigen Der p1 on the treatment of child asthma attack. PATIENTS AND METHODS A total of 96 children with asthma attack were included into the study. The patients were randomly divided into the PM2.5 group, the house dust mite antigen group, the synergistic group and the control group (n= 24 in each group). RESULTS The PM2.5 co...

In a double blind, controlled trial, the effect of high dose beclomethasone dipropionate (750 micrograms three times daily for five days) administered by metered dose inhaler and valved spacer, was compared with placebo, during 70 paired episodes of acute asthma in 24 preschool children. Treatment commenced at home at the first sign of an attack. Parents' blind preference for active treatment w...

In this review we discuss the potential of a new procedure, termed Bronchial Thermoplasty to prevent serious consequences resulting from excessive airway narrowing. The most important factor in minimizing an asthmatic attack is limiting the degree of smooth muscle shortening. The premise that airway smooth muscle can be either inactivated or obliterated without any long-term alteration of other...

The optimal amount of systemic corticosteroids to be used in acute severe asthma remains an unresolved issue. In this double-blind, randomized study we compared two doses of methylprednisolone (1 vs 6 mg.kg-1 q.d.) in asthmatics presenting with an acute severe asthma attack, unresponsive to an intensive beta 2-agonist regimen administered during a run-in period. Concurrent therapy, including ox...