BACKGROUND Disputes exist regarding the psychometric properties of the Oswestry Disability Index (ODI). The present study was to examine the reliability, validity, and dimensionality of a Chinese version of the ODI version 2.1 in a sample of 225 adult orthopedic outpatients with chronic low back pain [mean age (SD): 40.7 (11.4) years]. METHODS We conducted reliability analysis, exploratory bi...

Abstract Remdesivir is the only FDA-approved drug for treatment of COVID-19 patients. The active form remdesivir acts as a nucleoside analog and inhibits RNA-dependent RNA polymerase (RdRp) coronaviruses including SARS-CoV-2. incorporated by RdRp into growing product allows addition three more nucleotides before synthesis stalls. Here we use synthetic chemistry, biochemistry cryo-electron micro...

OBJECTIVE To study the influence of obstructive sleep apnea (OSA) on 24-h BP. SETTING Sleep laboratory of the Medical Department, Neukölln Hospital, Berlin, Germany. METHODS In 93 subjects, noninvasive 24-h BP monitoring was performed with BP recordings made at 15-min intervals. Apnea severity was evaluated by means of a portable device that allows calculation of an oxygen desaturation inde...

The current study investigated the night-to-night variability and diagnostic accuracy of the oxygen desaturation index (ODI), as measured by ambulatory monitoring, in the diagnosis of mild and moderate obstructive sleep apnoea-hypopnoea syndrome. To assess the variability of the ODI, 35 patients were monitored at home during 7 consecutive nights by means of a portable recording device, the MESA...

Background: Lumbar Canal Stenosis (LCS) is the most common reason for spinal surgery in older patients. Identifying factors influencing the outcome of surgical management is important in clinical research. Objectives: This study aims to identify the factors affecting the outcome of surgical management for LCS. Materials & Methods: This prospective non-randomized cohort study was conducted at ...

STUDY DESIGN Prospective longitudinal validation study. OBJECTIVE To translate and cross-culturally adapt the Oswestry Disability Index (ODI) to the Tamil language (ODI-T), and to evaluate its reliability and construct validity. SUMMARY OF BACKGROUND DATA ODI is widely used as a disease specific questionnaire in back pain patients to evaluate pain and disability. A thorough literature searc...

BACKGROUND Polysomnography (PSG) is currently the "gold standard" for the diagnosis of the sleep apnoea hypopnoea syndrome (SAHS). Nocturnal oximetry (NO) has been used with contradictory results. A prospective study was performed to determine the accuracy of NO as a diagnostic tool and to evaluate the reduction in the number of PSGs if the diagnosis of SAHS had been established by this method....

BACKGROUND Interlaminar epidural steroid injection (ESI) is a well-established intervention to improve radicular leg pain. However, few studies have demonstrated the prognostic factors for interlaminar ESI. OBJECTIVE To investigate the clinical effectiveness and prognostic indicators of parasagittal interlaminar ESI during a 2-week follow-up. STUDY DESIGN Prospective evaluation. SETTING A...

There has been indication of correlation between periodontal disease and metabolic syndrome. Reports including review article suggest a triangular relationship between the trios of diabetes, obesity and periodontitis. However, the extent of the correlation has neither been defined, nor data generated to substantiate the correlations. This population-based study investigated the relationship in ...

OBJECTIVES In its guidelines on the use of portable monitors to diagnose obstructive sleep apnoea, the American Academy of Sleep Medicine endorses home polygraphy with type III devices recording at a minimum airflow the respiratory effort and pulse oximetry, but advises against simple pulse oximetry. However, oximetry is widely available and simple to use in the home. This study was designed to...