BACKGROUND Comparing survival of patients with a single tumour and patients with multiple primaries poses different methodological problems. In population based studies, where we cannot rely on detailed clinical information, the issue is disentangling the share of survival probability from the first and second cancer, and their compounded effect. We examined three hypotheses: A) the survival pr...

In recent years there has been notable interest in additive models of sensory integration. Binaural additivity has emerged as a main hypothesis in the loudness-scaling literature and has recently been asserted by authors using an axiomatic approach to psychophysics. Restrictions of the range of stimuli used in the majority of former experiments, and inherent weaknesses of the axiomatic study by...

The protection of human health from the adverse effects of cumulative environmental exposure to chemical mixtures is an important issue. Of particular interest is the detection and characterization of interaction among chemicals in complex mixtures. Response surface methodology, often supported by factorial designs, is the classical statistical experimental approach. Fixed-ratio ray designs, wh...

We have investigated the dispersion interaction in hydrogen chain models via density functional theory-based symmetry-adapted perturbation theory using the asymptotically corrected PBE0 energy functional. The quasimetallic and the insulating prototype systems were chosen to be hydrogen chains with equally and alternately spaced H(2) units, respectively. The dependence of the dispersion energy o...

Under Martin’s axiom, collapsing of the continuum by Sacks forcing S is characterized by the additivity of Marczewski’s ideal (see [4]). We show that the same characterization holds true if d = c proving that under this hypothesis there are no small uncountable maximal antichains in S. We also construct a partition of 2 into c perfect sets which is a maximal antichain in S and show that s-sets ...

I evolved boolean regulatory networks in a computer simulation. I varied mutation, recombination, the size of the network, and the number of connections per node. I measured the performance of networks and the heritability and epistasis of genetic effects. Networks of intermediate connectivity performed best. The distinction between metabolic and quantitative genetic additivity explained some o...