Helicobacter pylori infection, excessive consumption of alcohol and the prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDS) are the major factors that cause peptic ulcer. Previous studies from our lab revealed the potency of the ethanol extract of the plant, Cardiospermum halicacabum Linn. against ethanol induced gastric ulcerogenesis in rats. The present study intended to compare th...

the aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of capparis zeylanica linn on experimental animal models. the methanol extract of capparis zeylanica linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. hcl-ethanol induced ulcer in mice and indomethacin induced ulcer in rats at...

Various studies have indicated that peptic ulcers occurring during the course of diabetic state are more severe and often associated with complications such as gastrointestinal bleeding. This study is an attempt to understand the pathogenesis of indomethacin-induced gastric ulcers occurring during the diabetic state using suitable markers and its amelioration by quercetin and coenzyme Q10 (CoQ1...

Background: Data suggest that V. arctostaphylos, B. thunbergii var. atropurpurea, E. angustifolia and L. acanthodes may prevent gastric ulcers induced by Non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. Methods: Saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/...

background: data suggest that v. arctostaphylos, b. thunbergii var. atropurpurea, e. angustifolia and l. acanthodes may prevent gastric ulcers induced by non-steroidal anti-inflammatory drugs (nsaids). objective: to explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. methods: saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) a...

objective(s):  this study was undertaken to investigate the protective effects of vitamin b6, cofactor for cystathionine-γ lyase and cystathionine-β synthase (producers of h2s), alone and in combination with l-cysteine, h2s precursor, on indomethacin-, and ethanol-induced gastric lesions in male nmri mice. materials and methods: fasted male nmri mice were randomly assigned into 12 groups (7 in ...

Flos Lonicerae is one of the oldest and most commonly prescribed herbs in Eastern traditional medicine to treat various inflammatory diseases. In the present study, we investigated the effects of ethyl acetate fraction of Flos Lonicerae (GC-7101) on experimental gastric ulcer models and its mechanisms of action in gastric ulcer healing. The pharmacological activity of GC-7101 was investigated i...

Indomethacin is a nonsteroid anti-inflammatory agent that is known to induce severe gastric mucosal lesions. In this study, we investigated the effect of selenium on gastric mucosal lesions in rats. To confirm the curative effect of selenium against indomethacin-induced gastric ulcers, gastric ulcers were induced by oral administration of 25 mg/kg indomethacin, and then different doses (10, 50,...

Introduction: The incidence rate of gastric erosions and ulcers in diabetic patients are higher due to failure of mucosal antioxidant defense and maintain enough blood flow. The present study evaluated the gastro-protective effect of sodium hydrosulfide (NaHS) against indomethacin-induced gastric lesions in diabetic rats. Methods: In order to test anti-ulcer activity of NaHS against indomet...

Abstract Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects rat model of indomethacin-induced gastric ulceration. Fustin itself has been ethanol-induced ulcer. In present study we aimed to reveal effect flavonoid isolated from was purified. The experiment performed on 30 male Wistar rats allocat...