نتایج جستجو برای: فولادapi grb
تعداد نتایج: 4533 فیلتر نتایج به سال:
The serine protease granzyme B (GrB; 25 kDa) is capable of inducing apoptosis through both caspase-dependent and caspase-independent mechanisms. We designed a novel vascular-targeting fusion construct designated as GrB/vascular endothelial growth factor (VEGF)121, which is composed of a non-heparin-binding isoform of VEGF and the proapoptotic pathway enzyme GrB fused via a short, flexible tethe...
We investigate the potentially observable prompt or delayed X-ray spectral features from the currently popular gamma-ray burst (GRB) models. During the evolution of many GRB progenitors, a disk around the central GRB source is produced. Shock heating as the GRB ejecta collide with the disk may produce observable X-ray features. We first summarize predictions deduced from previous calculations w...
Despite the pre-Swift expectation that bright optical flashes from reverse shocks would be prevalent in early-time afterglow emission, rapid response observations show this not to be the case. Although very bright at early times, some GRBs such as GRB 061007 and GRB 060418, lack the short-lived optical flash from the reverse shock within minutes after the GRB. In contrast, other optical aftergl...
Multiple sclerosis (MS) is considered an autoimmune disease of the CNS and is characterized by inflammatory cells infiltrating the CNS and inducing demyelination, axonal loss, and neuronal death. Recent evidence strongly suggests that axonal and neuronal degeneration underlie the progression of permanent disability in MS. In this study, we report that human neurons are selectively susceptible t...
The synchrotron self-Compton (SSC) emission from Gamma-ray Burst (GRB) forward shock can extend to the very-high-energy (VHE; Eγ >100 GeV) range. Such high energy photons are rare and are attenuated by the cosmic infrared background before reaching us. In this work, we discuss the prospect to detect these VHE photons using the current ground-based Cherenkov detectors. Our calculated results are...
Since the launch of the highly successful and ongoing Swift mission, the field of gamma-ray bursts (GRBs) has undergone a revolution. The arcsecond GRB localizations available within just a few minutes of the GRB alert has signified the continual sampling of the GRB evolution through the prompt to afterglow phases revealing unexpected flaring and plateau phases, the first detection of a kilonov...
We show that the clumpy structure of star-forming regions can naturally explain the fact that 50-70% of GRB afterglows are optical“dark.” We also show that dust echos from the GRB and its afterglow, produced by the clumpy structure of the star-forming region in which the GRB occurs, can lead to temporal variability and peaks in the NIR, optical, and UV lightcurves of GRB afterglows.
Natural killer (NK) cells are highly specialized effectors of the innate immune system that hold promise for adoptive cancer immunotherapy. Their cell killing activity is primarily mediated by the pro-apoptotic serine protease granzyme B (GrB), which enters targets cells with the help of the pore-forming protein perforin. We investigated expression of a chimeric GrB fusion protein in NK cells a...
The serineprotease granzymeB (GrB) induces apoptosis throughboth caspase-dependent and -independent multiple-cascade mechanisms. VEGF121 binds to both VEGF receptor (VEGFR)-1 and VEGFR-2 receptors. We engineered a unique GrB/VEGF121 fusion protein and characterized its properties in vitro and in vivo. Endothelial and tumor cell lines showed varying levels of sensitivity to GrB/VEGF121 that corr...
Context. Gamma-ray bursts (GRBs) have proven to be detectable to distances much larger than any other astrophysical object, providing the most effective way, complementing ordinary surveys of studying the high redshift universe. Aims. We present the results of an observational campaign devoted to the study of the high-z GRB 090205. Methods. We carried out optical/NIR spectroscopy and imaging of...
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