BACKGROUND AND OBJECTIVES Bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bacterial compounds such as some thiazole and imidazole derivatives. Thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on Bacillus cereus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Pro...

Abstract Amino acid decorated imidazole, pyrimidine and purine derivatives, resembling analogues of peptide nucleic acid's building blocks, have been synthesized by a three‐way multicomponent chemistry diaminomaleonitrile, one the most studied chemical precursors in prebiotic chemistry. The regioselectivity reaction between trimethyl orthoacetate selected panel α‐amino acids, was controlled ene...

A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a- 1e). The compounds were characterized by FT-IR, (1)H-NMR and mass spectra. The synthesized compounds were evaluated for the antimicrobial activity against Staphyl...

Over the past two decades a significant increase in fungal infections has been observed (1). More than any other antifungal class, the azoles have been steadily refined and improved upon over the course of almost 50 years. These antifungal compounds are chemically either an imidazole or a triazole group joined to carbon atom as their functional pharmacophore and working through blocking the act...

in the present study, an attempt has been made to synthesize 3-methyl-4-arylmethylene isoxazole-5(4h)-one derivatives through sonication of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives in the presence of imidazole as a novel and effective catalyst in aqueous media. this green reaction under ultrasound irradiation has advantageous compared to conventional procedur...