There is a paucity of strong evidence associated with adverse pregnancy outcomes and thrombophilia in pregnancy. These problems include both early (recurrent miscarriage) and late placental vascular-mediated problems (fetal loss, pre-eclampsia, placental abruption and intra-uterine growth restriction). Due to poor quality case-control and cohort study designs, there is often an increase in the ...

Aim of the study To evaluate the value of uterine artery Doppler indices and waveform pattern in predicting fetuses at risk for intrauterine growth restriction in hypertensive disorders of pregnancy. Materials and methods This was a prospective cross-sectional study including 80 pregnant subjects with hypertensive disorders of pregnancy and two control groups. Uterine artery Doppler sonograph...

OBJECTIVES To investigate whether, in women with abnormal uterine artery Doppler, platelet volume and function will identify a subgroup of women at increased risk of pre-eclampsia and intrauterine growth restriction and whether in-vitro platelet aggregation precedes the onset of clinical disease. DESIGN Platelet number, volume and aggregation induced by collagen or adenosine 5'-diphosphate we...

All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association. Pre-eclampsia and intrauterine growth restriction remain important causes of maternal and neonatal complications and death. These 2 conditions are felt to be the result of abnormal placenta formation involving abnormal trophoblast invasion of spiral arteries and a r...