The IL-2R is composed of at least two subunits, the p55 (CD25/Tac) and p75 glycoproteins. The p75 IL-2R is expressed preferentially on resting human peripheral blood NK cells, but is not detected on substantial proportions of T and B lymphocytes, monocytes, or granulocytes. Anti-p75 IL-2R mAb substantially inhibits the early events associated with NK cell activation by IL-2, including inhibitio...

We prove the nonexistence of a distance-regular graph with intersection array {74,54,15;1,9,60} and of distance-regular graphs with intersection arrays { 4r3 + 8r2 + 6r + 1,2r(r + 1)(2r + 1),2r2 + 2r + 1;1,2r(r + 1), (2r + 1)(2r2 + 2r + 1)} with r an integer and r 1. Both cases serve to illustrate a technique which can help in determining structural properties for distance-regular graphs and as...

For k > 1, r 6= 0 and large x, let π 2r (x) denote the number of prime pairs (p, p+2r) with p ≤ x. By the Bateman–Horn conjecture the function π 2r(x) should be asymptotic to (2/k)C k 2rli2(x), with certain specific constants C 2r . Heuristic arguments lead to the conjecture that these constants have mean value one, just like the Hardy–Littlewood constants C2r for prime pairs (p, p + 2r). The c...

Soluble interleukin-2 receptor (sIL-2R) is a marker of T-lymphocyte activation. We have undertaken a study to examine the serum sIL-2R levels in patients with pulmonary tuberculosis (TB) and the changes following anti-TB chemotherapy. Forty four patients with pulmonary TB or tuberculous pleural effusion were recruited. Serum was collected from the patients before and at 1, 2, 4 and 6 months aft...

NK/T-cell ratios predict disease activity in relapsing remitting multiple sclerosis (RRMS). We investigated 50 RRMS patients whether interleukin-2 receptor alpha-chain (IL-2R?) expression and shedding associates with balance, as suggested by daclizumab-trials RRMS. A subsample (N = 31) was genotyped for IL2RA-associated MS risk SNPs. CD56bright NK-cell/IL-17A+CD4+ T-cell correlated negatively p...

A graph is called radially maximal if it not complete and the addition of any new edge decreases its radius. In 1976 Harary Thomassen proved that radius $r$ diameter $d$ satisfy $r\le d\le 2r-2.$ Dutton, Medidi Brigham rediscovered this result with a different proof in 1995 they posed conjecture converse true, is, are positive integers satisfying 2r-2,$ then there exists $d.$ We prove little mo...

This study was undertaken to determine if advanced epithelial ovarian cancer was associated with increased serum and ascitic levels of soluble interleukin-2 receptor alpha (sIL-2R alpha). Serum and ascitic fluid samples from 23 ovarian cancer patients were analyzed for sIL-2R alpha using an enzyme-linked immunosorbent assay and compared with the serum and peritoneal levels in 18 normal females....

A direct approach to investigating new gene origination is to examine recently evolved genes. We report a new gene in the Drosophila melanogaster subgroup, Drosophila nuclear transport factor-2-related (Dntf-2r). Its sequence features and phylogenetic distribution indicate that Dntf-2r is a retroposed functional gene and originated in the common ancestor of D. melanogaster, D. simulans, D. sech...

We report here the presence of very high serum levels of the soluble interleukin-2 receptor (sIL-2R) in patients with blood hypereosinophilia with or without detectable markers of malignancy or signs of visceral involvement. The highest sIL-2R levels were observed in 16 eosinophilic patients with T-cell lymphoma (3,440 to 79,500 U/mL). Elevated levels of sIL-2R were also present (1,330 to 22,50...

Elevated soluble interleukin-2 receptor (sIL-2R) in sera is observed in patients with malignant lymphoma (ML). Therefore, sIL-2R is commonly used as a diagnostic and prognostic marker for ML, but the mechanisms responsible for the increase in sIL-2R levels in patients with B-cell lymphomas have not yet been elucidated. We first hypothesized that lymphoma cells expressing IL-2R and some proteina...