Perforin is an important mediator of inflammatory reactions. It is a quick-action cytotoxic mediator accumulated in the cytoplasmic granules of effector immunity cells (T lymphocytes, NK and NKT cells) which provide death signal in infected or transformed cells. Perforin-positive cells were previously detected in myocardial tissue during Trypanosoma cruzi infection and viral myocarditis while i...

OBJECTIVES To investigate the characteristics of the acute coronary syndromes underlying acute pulmonary oedema and their 30 day prognosis. PATIENTS 185 consecutive patients with acute coronary syndromes and acute pulmonary oedema admitted to a tertiary care centre. MAIN OUTCOME AND MEASURES Clinical, ECG, echocardiographic, enzymatic, and angiographic features were prospectively investigat...

BACKGROUND Limited recent data are available describing differences in long-term survival, and factors affecting prognosis, after ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI), especially from the more generalizable perspective of a population-based investigation. The objectives of this study were to examine differences in post-di...

Coronary angiography is an invasive procedure that utilises X-ray imaging and contrast medium to visualise the coronary vasculature guide management. Current National Institute for Health Care Excellence guidance aims provide within 72-hours patients with high-risk (GRACE>3%) non-ST elevation myocardial infarction (NSTEMI) late-presenting (>12 hours) ST-elevation (STEMI).

Acute coronary syndrome (ACS) refers to any constellation of clinical symptoms that are compatible with acute myocardial ischemia. ACS is divided into ST- elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), and unstable angina (UA). STEMI results from complete and prolonged occlusion of an epicardial coronary blood vessel and is defined based on ECG criteria....

Variation in practice regarding pretreatment with dual antiplatelet therapy for patients with non–ST elevation myocardial infarction. Background-—Despite guideline recommendations, a significant number of patients with non–ST elevation myocardial infarction (NSTEMI) do not receive dual antiplatelet therapy (DAPT) before angiography " pretreatment. " While there may be valid clinical reasons to ...

BACKGROUND Differences in plasma and whole blood expression microRNAs (miRNAs) in patients with an acute coronary syndrome (ACS) have been determined in both in vitro and in vivo studies. Although most circulating miRNAs are located in the cellular components of whole blood, little is known about the miRNA profiles of whole blood subcomponents, including plasma, platelets and leukocytes in pati...

BACKGROUND Current guidelines recommend thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI); however, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI). METHODS/DESIGN The TATORT-NSTEMI (Thrombus Aspiration in ThrOmbus containing culpRiT lesions in Non-ST-Elevation Myocardial Infarction) trial is a prospective, co...

Unstable angina (UA) and non ST segment elevation myocardial infarction (NSTEMI) is one of common ischemic sign of acute coronary syndrome (ACS), a serious emergency medical condition and majority of patients admitted with chest pain, affecting citizens at younger ages leading to more death and disability in lowand middle-income countries thereby having a greater economic impact. The study aim ...