Acute Coronary Syndromes (ACS) consists of mainly acute ST-segment elevation myocardial infarction (STEMI), non ST-segment elevation myocardial infarction (Non-STEMI) and unstable angina (UA). Despite the advances in detection, treatment and management of ACS, it continuous to be a significant contributor to mortality and morbidity attributed to Cardiovascular Diseases (CVD), even in developing...

AIMS To examine age-dependent in-hospital mortality for hospitalization with acute coronary syndromes (ACS) in England and Wales. METHODS AND RESULTS Mixed-effects regression analysis using data from 616 011 ACS events at 255 hospitals as recorded in the Myocardial Ischemia National Audit Project (MINAP) 2003-2010; 102 415 (16.7%) patients were aged <55 years and 72 721 (11.9%) ≥85 years. Pat...

BACKGROUND Negative T wave and lack of ST segment elevation in predischarge ECG in ST-segment elevation myocardial infraction (STEMI) patients are given as markers of good prognosis. Repolarization duration, especially its late part (TpeakTend - TpTe), likewise ST-T patterns, is related to local post-myocardial infarction myocardial attributes. We analyzed the differences in QT parameters in ST...

BACKGROUND Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible patients with STEMI. We conducted a randomized study to compare the efficacy and safety of a PhI strategy with half-dose fibrinolytic regimen versus...

Takotsubo cardiomyopathy (TCM) is usually characterized by transient left ventricular apical ballooning. Due to the clinical symptoms which include chest pain, electrocardiographic changes, and elevated myocardial markers, Takotsubo cardiomyopathy is frequently mimicking ST-elevation myocardial infarction in the absence of a significant coronary artery disease. Otherwise an acute occlusion of t...

Many patients with ST-segment elevation myocardial infarction (STEMI) have multivessel coronary artery disease (CAD) (1,2), yet interventional cardiologists can almost always identify a single lesion responsible for the infarction. After successful percutaneous coronary intervention of the infarct-related lesion (culprit PCI), there are 2 competing strategies available for STEMI patients with m...

A 73-year-old male was brought into hospital with chest pain and inferior ST elevation on ECG. The patient immediately proceeded to the catheter lab for primary percutaneous coronary intervention. Angiography did not identify any culprit lesions to account for the patient's electrocardiographic changes and ongoing symptoms of chest pain. Bedside echocardiography revealed critical aortic stenosi...

Background Left atrium (LA) is an important predictor of cardiovascular morbidity and mortality. Data related to LA functional changes during acute MR after ST-segment elevation myocardial infarction (STEMI) are limited. CMR is rapidly evolving imaging modality and feature tracking becomes very promising technique for assessment of myocardial deformation. The aim of this study was to investigat...

Since the earliest days of the thrombolytic era, maximizing myocardial salvage by reperfusion of the myocardial region at risk for myocardial infarction has been the most important immediate objective in management of ST-segment elevation myocardial infarction (STEMI) (1). The roles of time to reperfusion and collateral flow to the infarct territory and their impact on early and late post-infar...

Primary percutaneous coronary intervention and thrombolysis remain therapies of choice for patients presenting with ST-segment elevation myocardial infarction (STEMI). Clinical outcome in the management of acute STEMI is dependent on myocardial reperfusion time and reperfusion strategies. Optimisation of these strategies should take into consideration logistical limitations of the local medical...