BACKGROUND A history of penicillin allergy in patients is common, but only 10-15 % are truly allergic. While the gold standard for diagnosing penicillin allergy is challenge, it is not recommended that this be done without first carrying out diagnostic skin testing. This is carried out with the major determinant benzylpenicilloyl (PPL) and the minor determinant mixture (MDM), consisting of peni...

Substance P (SP) is a potent modulator of neuroimmunoregulation. We recently reported that human immune cells express SP and its receptor. We have now investigated the possible role that SP and its receptor plays in HIV infection of human mononuclear phagocytes. SP enhanced HIV replication in human blood-isolated mononuclear phagocytes, whereas the nonpeptide SP antagonist (CP-96,345) potently ...

The Modified Direct Method (MDM) is an iterative mesh smoothing method for smoothing planar and surface meshes, which is developed from the non-iterative smoothing method originated by Balendran [1]. When smooth planar meshes, the performance of the MDM is effectively identical to that of Laplacian smoothing, for triangular and quadrilateral meshes; however, the MDM outperforms Laplacian smooth...

Great strides have been made in the optical interconnect for a mode-division multiplexing (MDM) system. The mode multiplexer/demultiplexer (MUX/DEMUX) is the crucial component for the MDM system. We propose and demonstrate a scheme that is different from the reported multiplexing schemes, mode MUX that tackles dual-path MDM signals simultaneously and avoids mode conflict. The performance is exp...

We introduce highly compact resonant-cavity-enhanced magneto-optical switches for metal-dielectric-metal (MDM) plasmonic waveguides. The field profile of the fundamental mode of a MDM waveguide in which the metal is subject to an externally applied static magnetic field is asymmetric. The static magnetic field induced asymmetry, which enhances or reduces the coupling between the waveguide and a...

Which children go on to develop dyslexia? Since dyslexia has a multifactorial etiology, this question can be restated as: what are the factors that put children at high risk for developing dyslexia? It is argued that a useful theoretical framework to address this question is Pennington's (2006) multiple deficit model (MDM). This model replaces models that attribute dyslexia to a single underlyi...

Lopez MA, Pardo PS, Cox GA, Boriek AM. Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttn) model. Am J Physiol Cell Physiol 295: C1092–C1102, 2008. First published August 27, 2008; doi:10.1152/ajpcell.16.2008.—A complex rearrangement mutation in the mouse titin gene leads to an in-frame 83-amino acid deletion in the N2A region of titin. Autosomal recessiv...

Mononuclear phagocytes (MP) and T lymphocytes play a pivotal role in the host immune response to human immunodeficiency virus type 1 (HIV-1) infection. Regulation of such immune responses can be mediated, in part, through the interaction of the T-lymphocyte-expressed molecule CD40 ligand (CD40L) with its receptor on MP, CD40. Upregulation of CD40L on CD4+ peripheral blood mononuclear cells duri...

Im Zuge stetig steigender Komplexität in Business-IntelligenceSystemen nimmt auch die Bedeutung des Metadatenmanagements (MDM) kontinuierlich zu. Die vorliegende Studie untersucht den Status Quo des MDM in der Business Intelligence (BI) aus Sicht der drei BI-Stakeholder-Typen Endanwender, Entwickler und Entscheider. Die Ergebnisse veranschaulichen, in welchen Anwendungsgebieten des MDM derzeit ...

The Cisco ISE can be configured to integrate with third-party Mobile Device Manager (MDM) products through an XML-based API. This allows network policy decisions based on mobile device posture that can include PIN lock, storage encryption, or registration status. In this release, both Apple and Android devices are supported. Configuring the infrastructure to support this functionality involves ...