Hemoglobin released into the circulation during hemolysis or therapy with chemically modified hemoglobins, exert oxidative and NO-scavenging toxic effects. Pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) is one of the second-generation hemoglobin-based oxygen carriers (HBOCs). We wanted to investigate the metabolism of PHP with a special focus on its consequences for interpreting hemol...

Pseudohypoparathyroidism (PHP) is a group of disorders characterized by end-organ resistance to the parathyroid hormone (PTH). PHP type 1A includes multihormone resistance syndrome, Albright's hereditary osteodystrophy, and obesity and is caused by mutations in GNAS exon 1 through 13. PHP type 1B (PHP1B), caused by epigenetic changes in the GNAS locus, was initially described as an isolated res...

Three new trifluoromethylated p-hydroxyphenacyl (pHP)-caged gamma-aminobutyric acid (GABA) and glutamate (Glu) derivatives have been examined for their efficacy as photoremovable protecting groups in aqueous solution. Through the replacement of hydrogen with fluorine, e.g., a m-trifluoromethyl or a m-trifluoromethoxy versus m-methoxy substituents on the pHP chromophore, modest increases in the ...

The use of the PHP programming language is a fastgrowing, and rapidly the language becomes mature enough to develop robust web-applications with. This paper investigates ways that model-driven principles can be exploited for PHP application development.

We investigated the effects of modified hemoglobin on regional blood flow and function of different organs during hyperdynamic sepsis. Fourteen sheep were surgically prepared for the study. After a 5-day recovery period, a continuous infusion of live Pseudomonas aeruginosa bacteria was begun and maintained for 48 h. At 24 h, after a hyperdynamic circulation had developed, the animals were rando...

The effective management of various health conditions depends on and requires appropriate public health policies (PHP). Such policies are important for several aspects of healthcare provision, including: (a) screening for prevention of disease; (b) early diagnosis and treatment; (c) long-term management of chronic diseases and disabilities; and (d) setting-up standards. Although it is widely re...

Primary hyperparathyroidism (PHP) is the third most common endocrine disorder after diabetes and thyroid disease. Women are affected twice as common as men (1). Although PHP is a very rare condition during pregnancy, it may cause feto-maternal morbidity and mortality (2). The prevalence of hyperparathyroidism in pregnancy varies from 0.15% to 1.4% (3). PHP occurs due to decreased negative feedb...

The present study describes how to process human postheparin plasma (PHP) containing hepatic triglyceride lipase (HTGL) that is utilized as a standard material of HTGL for the quantification of HTGL mass in human plasma. The optimal storage conditions for PHP were established by monitoring the stability of HTGL molecules in PHP as an antigen, which was stored in the liquid, frozen, or lyophiliz...

Parathyroid hormone (PTH) plays a critical role in calcium and phosphorus metabolism. Interestingly, in two forms of hyperparathyroidism (excessive amount of PTH in the serum), the metabolic disturbances in patients with chronic kidney disease (CKD) significantly differ from those with primary hyperparathyroidism (PHP). Since an intuitive understanding of these PTH-linked regulatory mechanisms ...

The World Wide Web grew rapidly during the last decades and is used by millions of people every day for online shopping, banking, networking, and other activities. Many of these websites are developed with PHP, the most popular scripting language on the Web. However, PHP code is prone to different types of critical security vulnerabilities that can lead to data leakage, server compromise, or at...