PURPOSE To develop a postprocessing method to correct saturation of arterial input function (AIF) in T1-weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for quantification of hepatic perfusion. MATERIALS AND METHODS The saturated AIF is corrected by parameterizing the first pass of the AIF as a smooth function with a single peak and minimizing a least-squares error in f...

PURPOSE Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) shows high sensitivity in detecting breast cancer. However, its performance could be affected by patient motion during the imaging. To overcome this problem, it is necessary to correct patient motion by deformable registration, before using the DCE-MRI to detect breast cancer. However, deformable registration of DCE-MR image...

Application of a multimodality imaging approach is advantageous for detection, diagnosis, and management of many ailments. Display is limited to two or three dimensions when using spatial relationships alone. The use of color, in addition to spatial relationships increases the dimensionality of the data that can be effectively visualized. A genetic algorithm has been developed to automatically ...

Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of a...

INTRODUCTION: 3D Time-Resolved Dynamic Contrast Enhanced MRI (DCE-MRI) is an important tool to depict anatomic and dynamic information (bolus pass) of thoracic vessels. The current limitation of this application is the requirement of both high spatial and temporal resolution. Several methods have been proposed to overcome this problem [1-3], however, these techniques usually need an accurate ti...

BACKGROUND Dynamic contrast enhanced MRI (DCE MRI) is able to reflect changes in vascularity, vessel permeability and extracellular diffusion space of tissues. The goal of this study was to investigate the use of DCE MRI to differentiate benign and malignant breast lesions. PATIENTS AND METHODS From a database, five patients with malignant and five patients with benign lesions were randomly c...