AIMS There have been no large observational studies attempting to identify predictors of major bleeding in patients with acute coronary syndromes (ACS), particularly from a multinational perspective. The objective of our study was thus to develop a prediction rule for the identification of patients with ACS at higher risk of major bleeding. METHODS AND RESULTS Data from 24045 patients from th...

A key problem in the emergency department is the prompt identification of patients with myocardial infarction. While this is not a diagnostic challenge in ST elevation myocardial infarction as the ECG is usually unmistakable, in non ST elevation myocardial infarction (NSTEMI) the diagnosis is more complex and based on information derived from detailed clinical assessment, ECG and biomarkers. Th...

BACKGROUND New guidelines recommend early invasive evaluation and treatment for most patients with acute myocardial infarction--including patients with myocardial infarction without ST elevation in the ECG. This study examines compliance with the new guidelines at Sørlandet Hospital Arendal. MATERIAL AND METHOD All patients admitted to Sørlandet Hospital Arendal with acute myocardial infarcti...

As a member of Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors, Tirofiban had been shown to improve myocardial reperfusion and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI), but the optimal timing of administration of Tirofiban remains unclear. In order to compare the effects of upstream versus downstream administration of Tirofiban in Chinese patients with mi...

Data from the Strategic Reperfusion Early After Myocardial Infarction (STREAM) trial(6) and 5-year results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)(7) are evaluated for further evidence on the effectiveness and safety of a pharmacoinvasive approach for patients presenting with acute ST-segment elevation myocardial infarction (STEMI).

We read with great interest the recent publication by Milosevic et al. (1) on the RIDDLE-NSTEMI (Randomized Study of Immediate Versus Delayed Invasive Intervention in Patients With Non-ST-Segment Elevation Myocardial Infarction) trial, and we congratulate the investigators on their important contribution to clarify the optimal timing of invasive management in non–ST-segment elevation acute coro...