This study aimed to investigate the in vitro skin permeation and in vivo antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated soybean phospholipids (HSPC) were selected for the preparation of different kinds of phospholipids composed of curcumin-loaded liposomes: C-SPC-L (curcumi...

A statistical associating fluid theory to model electrolyte fluids that explicitly accounts for solvent molecules by modeling water as a dipolar square-well associating fluid is presented. Specifically the statistical associating fluid theory for potentials of variable range (SAFT-VR) is combined with integral equation theory and the generalized mean spherical approximation using the nonprimiti...

Nitriles are strong polar compounds showing a highly non-ideal behavior, which makes them challenging systems from a modeling point of view; in spite of this, accurate predictions for the vapor-liquid equilibria of these systems are needed, as some of them, like acetonitrile (CH3CN) and propionitrile (C2H5CN), play an important role as organic solvents in several industrial processes. This work...

Friction stir welding (FSW) is a recently developed solid-state joining process that uses a specially shaped rotating tool to produce lap or butt joints. At the National Research Council, an inter-institute collaboration was started in 2007 with the goal of exploiting the NDE expertise and applying it for the characterization of friction stir welds for various industrial applications. In partic...

Mesenchymal stem cells (MSCs) can differentiate into diverse cell types including adipogenic, osteogenic, chondrogenic and myogenic lineages. In the present study, we demonstrated for the first time that sphingosylphosphorylcholine (SPC) induces differentiation of human adipose-tissue-derived mesenchymal stem cells (hATSCs) to smooth-muscle-like cell types. SPC increased the expression levels o...

INTRODUCTION The use of dipeptidyl peptidase-4 inhibitors in combination with metformin is increasing in Japanese patients with type 2 diabetes mellitus (T2DM), but no single-pill combination (SPC) is currently available in Japan. The objective of this study was to assess the efficacy and safety of vildagliptin/metformin SPC in Japanese patients with T2DM inadequately controlled with vildaglipt...

This paper investigates the Triangle Single Parity Check (T/SPC) code, a novel class of high-rate low-complexity LDPC codes. T/SPC is a regular, soft decodable, linear-time encodable/decodable code. Compared to previous high-rate and low-complexity LDPC codes, such as the well-known Turbo Product Code / Single Parity Check (TPC/SPC), T/SPC provides higher code rates, shorter code words, and low...

High-pressure phase equilibrium and volumetric properties of highly asymmetric mixtures related to reservoir fluids are critical the development high-pressure high-temperature (HPHT) reservoirs. However, there is a lack relevant data accurate modeling tools. In this work, we prepared pseudo-binary methane (CH4) + stock tank oil (STO) systematically measured their densities at temperatures from ...

We compared the microscopic structure of liquid water at ambient conditions predicted by six classical intermolecular potential models. Applying their accepted acronyms were the SPC (Simple Point Charge), SPC/E (SPC extended), MSPC/E (SPC/E modified), TIP4P (Transferable Intermolecular Potential, four point charges), TIP5P (TIP, five point charges), and the PPC (Polarizable Point Charge) interm...