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نتایج جستجو برای 1 Perforin Proviral load

تعداد نتایج: 2154412  

Objective(s): Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of northeastern Iran.Materials and Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary an...

2014
Finja Schweitzer, Visa Mikkola, Monika Timmen-Wego, Björn Jensen, Gerd Fätkenheuer, Rolf Kaiser,

INTRODUCTION The goal of antiretroviral treatment (ART) in HIV-1 infection is the permanent suppression of plasma viral load (pVL) below the currently existing limit of detection of 50 copies/mL (DAIG HIV-therapy guidelines). Therefore, treatment effectiveness is based on pVL. pVL measurements however do not give any information about the viral reservoir in peripheral blood mononuclear cells (P...

Ghasemzadegan, H., Rezaei, N., Shahabi, M., Sharifi, Z.,

Abstract Background and Objectives In Iran, Khorasan province is an endemic area for HTLV-1 virus. Considering the inability of serological tests to determine HTLV-1 in window period, their failure to confirm the indetermination results of western blot, and given the probability for HTLV-1 transfusion transmission, a SYBR green-based Real Time PCR was set to measure the HTLV-1 proviral load.  ...

2012
Gerónimo Gutiérrez, Hugo Carignano, Irene Alvarez, Cecilia Martínez, Natalia Porta, Romina Politzki, Mariela Gammella, Marina Lomonaco, Norberto Fondevila, Mario Poli, Karina Trono,

BACKGROUND Bovine leukemia virus (BLV) is worldwide distributed and highly endemic in Argentina. Among the strategies to prevent BLV dissemination, a control plan based on the selective segregation of animals according to their proviral load (PVL) is promising for our dairy productive system. The objective of this work was to study the relationship between the blood PVL and the antibody level, ...

2016
Benjamin Usadi, Roberta Bruhn, Jue Lin, Tzong-Hae Lee, Elizabeth Blackburn, Edward L. Murphy,

Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-cell lymphotropic virus type 1 (HTLV-1), 45 human T-cell lymphotropic virus ty...

2016
Clara Mônica Lima, Silvane Santos, Adriana Dourado, Natália B. Carvalho, Valéria Bittencourt, Marcus Miranda Lessa, Isadora Siqueira, Edgar M. Carvalho,

The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy....

Journal: :Journal of clinical microbiology 2001
N Désiré, A Dehée, V Schneider, C Jacomet, C Goujon, P M Girard, W Rozenbaum, J C Nicolas,

Proviral human immunodeficiency virus type 1 (HIV-1) DNA could be a useful marker for exploring viral reservoirs and monitoring antiretroviral treatment, particularly when HIV-1 RNA is undetectable in plasma. A new technique was developed to quantify proviral HIV-1 using a TaqMan real-time PCR assay. One copy of proviral HIV-1 DNA could be detected with 100% sensitivity for five copies and the ...

2009
Jun Yong Choi, Young Goo Song, Young Hwa Kim, Chang Oh Kim, Myung Soo Kim, Bum Sik Chin, Sang Hoon Han, Suk Hoon Choi, Han Sung Lee, Su Jin Jeong, Heekyoung Choi, June Myung Kim,

To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1-infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA wh...

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2012
Viviana Nilla Olavarria, Alline do Nascimento Gomes, Ramon de Almeida Kruschewsky, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi,

INTRODUCTION Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. OBJECTIVE To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. METHODS A group of 104 HTLV-1 infected patients, followed at the HTLV...

Journal: :Revista da Sociedade Brasileira de Medicina Tropical 2006
Bruna Pedroso Tamegão-Lopes, Priscila Rocha Rezende, Luciana Maria Cunha Maradei-Pereira, José Alexandre Rodrigues de Lemos,

When the human T cell lymphotropic virus (HTLV) is integrated with the host cell genome (provirus), its proviral DNA is a replication marker. Proviral load appears to be an important factor in the development of diseases related to these retroviruses. In this study, a methodology for absolute quantification of the HTLV-1 and HTLV-2 proviral load using real-time PCR was developed. Fifty-three bl...