14-3-3 ��

So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...

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Serum 14-3-3-eta

2014

Anthony Marotta, Rania W. Abolhosn, Joanna M. Popov, Karin Britsemmer, Arno W. van Kuijk, Mark C. Genovese, Michael E. Weinblatt, Edward C. Keystone, Dirkjan van Schaardenburg, Maarten Boers, Robert Landewé, Désirée van der Heijde, Walter P. Maksymowych, Stanley J. Naides, Vivian Bykerk, Katherine A. Siminovitch, Paul-P. Tak, Olga S. Zhukov,

Objective. Serum 14-3-3η is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis (RA). In our study, we assessed the diagnostic utility of 14-3-3η and its association with standard clinical and serological measures. Methods. A quantitative ELISA was used to assess 14-3-3η levels. Early (n = 99) and established patients with RA (n = 135) were comp...

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