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Cell-permeating esters of 2-ketoglutarate (2-KG) have been synthesized through a convergent sequence from two modules in two and three steps, respectively. This route provides access to a full series of monoand disubstituted 2-KG esters, enabling us to define the effect of regioisomeric masking on metabolite release and antihypoxic activity in cell-based assays. In addition to providing insight...

Solar cells and photodetectors are devices that convert an optical input into current. A solar cell is an example of a photovoltaic device, i.e, a device that generates voltage when exposed to light. The photovoltaic effect was discovered by Alexander-Edmond Becquerel in 1839, in a junction formed between an electrode (platinum) and an electrolyte (silver chloride). The first photovoltaic devic...

During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also involved in establishing the checkpoint and maintaining SAC signalling. However, mechanistically, ...

1Department of Biostatistics and Epidemiology, Shiraz University of Medical Sciences, School of Health, Shiraz, Islamic Republic of Iran (Correspondence to S.M.T. Ayatollahi: [email protected]). Received: 18/09/02; accepted: 07/10/03 ABSTRACT With increasing life expectancy, menopause is an increasingly important aspect of women’s health. We recorded the age at natural menopause among women...

A new Skew Tolerant Flip-Flop (STFF) that achieves the lowest reported delay and energy-delay product while absorbing up to 54ps of clock skew is described. In addition, a method for characterizing clock skew absorbing flip-flops is presented. This comparison is apples-to-apples because the best previously reported flip-flops [1-4] are fabricated on the same wafer and measured using a common te...

The research of 60GHz CMOS transceivers has bloomed due to their capability of achieving low-cost multi-Gb/s short-range wireless communications [1]. Considering practical use of the 60GHz CMOS transceivers, longer operation lifetime with high output power is preferred to provide reliable products. Unfortunately, as indicated in [2], the output power capability of the transmitter will gradually...