Maternal consumption of a high-fat diet (HFD) during pregnancy and lactation is closely related to hepatic lipid accumulation, insulin resistance and increased serum cytokine levels in offspring and into their adulthood. MicroRNA (miRNA) have been implicated in cholesterol biosynthesis and fatty acid metabolism. We evaluated the modulation of hepatic fatty acid synthesis (de novo), β-oxidation ...

Continuous in situ measurements of aerosol optical properties were conducted from 29 June to 29 July 2012 in Granada (Spain) with a seven-wavelength Aethalometer, a Multi-Angle Absorption Photometer, and a three-wavelength integrating nephelometer. The aim of this work is to describe a methodology to obtain the absorption coefficients (babs) for the different Aethalometer wavelengths. In this w...

Emergency air medical transport (EAMT) is indispensable for acutely or critically ill patients in remote areas. We determined patient-level and transport-specific factors associated with all-cause mortality after EAMT.We conducted a population-based, retrospective cohort study using a prospective registry consisting of clinical/medical records. Study inclusion criteria consisted of all adults u...

Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes and antioxidant enzymes in response to many cancer chemopreventive compounds. In this study, we investigated the role of receptor associated coactivator (RAC3) or steroid receptor coactivator-3 (SRC3) and other nuclear co-regulators including CBP/p300 (CREB-binding protein), CARM1(Coactiva...

The early days The origins of VMs go back almost as far as modern computing itself. Born to optimize usage of expensive computing resources and provide users with a fully dedicated and interactive computer system, the early 1960s experiences in time-sharing systems at MIT, IBM, Bolt Beranek and Newman (now BBN Technologies), and the University of California, Berkeley, laid the foundations on wh...

The early days The origins of VMs go back almost as far as modern computing itself. Born to optimize usage of expensive computing resources and provide users with a fully dedicated and interactive computer system, the early 1960s experiences in time-sharing systems at MIT, IBM, Bolt Beranek and Newman (now BBN Technologies), and the University of California, Berkeley, laid the foundations on wh...