The importance of p-aminosalicylic acid in the treatment of tuberculosis has been demonstrated both clinically and experimentally (l-6). The close structural relationships between benzoic, salicylic, p-aminobenzoic (PABA), and p-aminosalicylic (PASA) acid warrant a comparative study of the metabolism of these substances in the animal body.* Recent workers, interested in the behavior of PABA in ...

BACKGROUND Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow relea...

Arylamine N-acetyltransferase activity has been described in various bacterial species. Bacterial N-acetyltransferases, including those from bacteria of the gut flora, may be involved in the metabolism of xenobiotics, thereby exerting physiopathological effects. We characterized these enzymes further by steady-state kinetics, time-dependent inhibition, and DNA hybridization in 40 species, mostl...

This report describes a patient who developed a Hodgkin's disease-like picture both clinically and pathologically, following the administration of para-aminosalicylic acid, with complete regression on cessation of therapy.

5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these o...

4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remission in Crohn's colitis. As treatment with 4-ASA may result in less side effe...

Objective(s): This study is aimed to design and synthesize a prodrug of 5-aminosalicylic acid and evaluate its ameliorative effect on experimental ulcerative colitis (UC).Materials and Methods: 5-Aminosalicylic acid-alanine (5-ASA-ALA) was synthesized and characterized. Its stability study was conducted in rat plasma and in the gastroint...

Amine-tagged defective Ni-MOF-74 was prepared by solvothermal synthesis using aminosalicylic acid as a functionalized fragmented ligand, described Seung Bin Baek, Myoung Soo Lah et al. in their Communication on page 9296. The covalent post-synthetic modification and subsequent metalation with palladium(II) ions affords palladium(II)-incorporated catalyst, which exhibits highly efficient, size-s...