نتایج جستجو برای 5-aminosalicylic acid

تعداد نتایج: 1380491  

Ardeshir Kermani, Jilla Khalighie, Mohammad Bagher Pasha Zanousi, Mohammad Saber Tehrani,

5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...

Journal: :British medical journal 1972
I C Calder, C C Funder, C R Green, K N Ham, J D Tange,

5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these o...

Journal: :Gut 1999
P Deltenre, A Berson, P Marcellin, C Degott, M Biour, D Pessayre,

BACKGROUND Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow relea...

Journal: :journal of physical & theoretical chemistry 2007
mohammad bagher pasha zanousi, mohammad saber tehrani, ardeshir kermani, jilla khalighie,

5-aminosalicylic acid (5-asa) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-nsa) in acidic media. in this work, electrolytic reduction of 5-nsa in alkaline media is presented. reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the ph for isolation of product are investigated. the yiel...

Journal: :Gut 1998
S A Riley,

Sulphasalazine was developed in the 1930s, initially for use in patients with rheumatic polyarthritis. However, its modest eVects in arthritis were soon overshadowed by the striking benefits seen when the drug was given to patients with active colitis. Controlled clinical trials confirmed the early favourable impressions and established a role for sulphasalazine in the treatment of active disea...

Journal: :World journal of gastroenterology 2007
T Moshkovska, J-F Mayberry,

The development of 5-aminosalicylic acid (5-ASA) therapy as a life long treatment for ulcerative colitis is reviewed from its origins in the 1940s to the present day. The drug was designed to treat rheumatoid arthritis, but was found helpful in the management of nine patients with ulcerative colitis. This discovery preceded the emergence of the clinical trial as a tool for assessing a new drug'...

Journal: :British medical journal 1988
B H Novis, Z Korzets, P Chen, J Bernheim,

reduced during the first six months by non-closure of the defect. Presumably non-closure allows cerebrospinal fluid to escape from the open neural tube, postponing the development of hydrocephalus until epithelium has formed. As deferred shunt operations are associated with a better prognosis,4 nonclosure may in fact be advantageous, delaying the onset of ventriculitis until the child is immuno...

Journal: :The Biochemical journal 1992
A Stolz, B Nörtemann, H J Knackmuss,

The metabolism of 5-aminosalicylate (5AS) by a bacterial strain, Pseudomonas sp. BN9, was studied. Intact cells of Pseudomonas sp. BN9 grown with 5AS oxidized 5AS and 2,5-dihydroxybenzoate (gentisate), whereas cells grown with gentisate oxidized only the growth substrate of all substituted salicylates tested. Cell extracts from Pseudomonas sp. BN9 catalysed the stoichiometric reaction of 1 mol ...

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