That para-aminobenzoic acid antagonizes competitively the inhibitory effect of paraaminosalicylic acid on the growth of Mycobacterium tuberculosis is well known. In a previous communication (Hedgecock, 1956) it was reported that inhibition of M. tuberculosis (strain H37Rv) by para-aminosalicylic acid was reversed noncompetitively by methionine and biotin when the concentration of the inhibitor ...

Schiff base, azetidinone and 4-thiazolidinone derivatives of para aminosalicylic acid were synthesised. It was planned to employ the structure based computer aided drug designing (CADD) to Schiff base, azetidinone and 4thiazolidinoneof para aminosalicylic acid. Approach was employed to understand the probable binding of para aminosalicylic acid on the active site of AMpC enzyme of HKY28 which w...

Two human acetyl-CoA:arylamine N-acetyltransferases (NAT1 and NAT2) have been identified. Therapeutic and carcinogenic agents that are substrates for these isoenzymes (including isoniazid, sulfamethazine, p-aminobenzoic acid, 5-aminosalicyclic acid, and 2-aminofluorene) have been used to evaluate the role of the N-acetylation polymorphisms of NAT1 and NAT2 in the treatment of disease and differ...