The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations an...

The ever-evolving research in the field of antitubercular agents has led to identification several new potential drug classes. Among them, 5-phenyl-furan-2-carboxylic acids have emerged as innovative therapeutics, targeting iron acquisition mycobacterial species. In our efforts characterize molecular interactions between these compounds and their protein target (MbtI from M. tuberculosis) by me...