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نتایج جستجو برای ATL Granzyme HTLV

تعداد نتایج: 6898  

Objective(s): Human T cell leukaemia virus type 1 (HTLV-1) is associated with adult T cell leukaemia (ATL), a malignant lymphoproliferative disease that infects CD4 T cells. It is not clear why the majority of HTLV-1-infected individuals remain asymptomatic carries (ACs) and a minority develop ATL. Cellular immune response has a critical role in ATL and destroys malign...

Journal: :Current opinion in virology 2015
Charles R M Bangham, Lee Ratner,

A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infecte...

2014
Gabriel Colțan, Cristina Marin, Mariana Anghel, Tatiana Colțan, Mihai Olariu, Ana Maria Vlădăreanu, Elena Ambrus, Irina Pârvu,

Infections with human retroviruses, others than the HIV virus, are not very well known in Romania, despite the fact that screenings for HTLV I and II are constantly performed in blood donation centers. The authors draw attention on the possible severe consequences that may occur in chronic infections with these viruses by presenting the case of a 35 year-old male, who was known to be infected w...

2013
Mohammad Mehdi Akbarin, Hossein Rahimi, Tahereh HassanNia, Ghazaleh Shoja Razavi, Faezeh Sabet, Abbas Shirdel,

OBJECTIVE(S) Human T Lymphocyte Virus Type one (HTLV-I) is a retrovirus that infects about 10-20 million people worldwide. Khorasan province in Iran is an endemic area. The majority of HTLV-I-infected individuals sustain healthy carriers but small proportion of infected population developed two progressive diseases: HAM/TSP and ATL. The proviral load could be a virological marker for disease mo...

Journal: :Virology 2007
Nicole S Harhaj, Branislava Janic, Juan C Ramos, William J Harrington, Edward W Harhaj,

HTLV-I infection is associated with the development of adult T cell leukemia (ATL) and the neuroinflammatory disease HAM/TSP. There are quantitative and qualitative differences in the antiviral cytotoxic T cell (CTL) response in ATL and HAM/TSP although the underlying mechanisms are unclear. Here, we demonstrate that the HTLV-I Tax trans-activating protein is a transcriptional activator of CD40...

2017
Laura Bozzelli, Aniello Murano,

Module checking has been introduced in late 1990s to verify open systems, i.e., systems whose behavior depends on the continuous interaction with the environment. Classically, module checking has been investigated with respect to specifications given as CTL and CTL∗ formulas. Recently, it has been shown that CTL (resp., CTL∗) module checking offers a distinctly different perspective from the be...

2017
Alison K. Esser, Daniel A. Rauch, Jingyu Xiang, John C. Harding, Nicole A. Kohart, Michael H. Ross, Xinming Su, Kevin Wu, Devra Huey, Yalin Xu, Kiran Vij, Patrick L. Green, Thomas J. Rosol, Stefan Niewiesk, Lee Ratner, Katherine N. Weilbaecher,

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy that occurs in HTLV-1 infected patients. Most ATL patients develop osteolytic lesions and hypercalcemia of malignancy, causing severe skeletal related complications and reduced overall survival. The HTLV-1 virus encodes 2 viral oncogenes, Tax and HBZ. Tax, a transcriptional activator, is critical to ATL development, and has...

2009
Alfons Laarman,

With the emergence of a number of model transformation languages the need for interoperability among them increases. The degree at which this interoperability can be achieved between two given languages depends heavily on their paradigms (declarative vs imperative). Previous studies have indicated that the QVT and ATL languages are compatible. In this paper we study the possibility to compile Q...

2009
Andrés Yie, Dennis Wagelaar,

Tracing information is an essential part of the ATLAS Transformation Language (ATL). It is used to support interaction between transformation rules, where each rule can use the output of other rules by means of the implicit tracing mechanism. However, tracing information is often useful outside the scope of the transformation execution as well. Currently, ATL offers limited access to the implic...