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نتایج جستجو برای Acute kidney injury Adipose tissue Ischemia

تعداد نتایج: 1229839  
2010
Zheng Feng, Joey Ting, Zeni Alfonso, Brian M. Strem, John K. Fraser, Joshua Rutenberg, Hai-Chien Kuo, Kai Pinkernell,

BACKGROUND Acute kidney injury (AKI) represents a major clinical problem with high mortality and limited causal treatments. The use of cell therapy has been suggested as a potential modality to improve the course and outcome of AKI. METHODS We investigated the possible renoprotection of freshly isolated, uncultured adipose tissue-derived stem and regenerative cells (ADRCs) before and after cr...

Objective(s): It has been shown that adipose-derived mesenchymal stem cells (AD-MSC) have protective effects in acute kidney injury (AKI). This study was conducted to assess the therapeutic effects of AD-MSC in rats subjected to acute kidney injury by 45 min of renal ischemia followed by 48 hr of reperfusion (I/R). Materials and Methods:...

Journal: :Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 2014
N Chatauret, L Badet, B Barrou, T Hauet,

Ischemia reperfusion injury occurs in the kidney when blood supply is interrupted in clinical settings such as kidney transplantation or nephron sparing surgery for renal tumors. These lesions lead to acute kidney injury (AKI) a detrimental situation associated with impaired short-term allograft function (delayed graft function or primary non function) but also long-term transplant survival thr...

Journal: :Cardiovascular & hematological disorders drug targets 2014
David P Basile, Mervin C Yoder,

Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and ...

Objective(s): There is increasing evidence for the importance of gender in different diseases; however, the role of gender in response to treatments is still unknown. Therefore, this study investigated the impact of gender on the protective effects of celecoxib in ischemia reperfusion (IR)-induced acute kidney injury.Materials and Methods: In this experimental study, rats were randomly divided ...

2016
HUSSEIN SHEASHAA, AHMED LOTFY, FATMA ELHUSSEINI, AZZA ABDEL AZIZ, AZZA BAIOMY, SAMAH AWAD, AZIZA ALSAYED, ABDEL-HADY EL-GILANY, MOHAMED-AHDY A.A. SAAD, KHALED MAHMOUD, FATEN ZAHRAN, DALIA A. SALEM, AHMED SARHAN, HASSAN ABDEL GHAFFAR, MOHAMED SOBH,

Acute kidney injury (AKI) is a complex clinical condition associated with significant morbidity and mortality and lacking effective management. Ischemia-reperfusion injury (IRI) remains one of the leading causes of AKI in native and transplanted kidneys. The aim of this study was to evaluate the efficacy of adipose-derived mesenchymal stem cells (ADSCs) in the prevention of renal IRI in rats. T...

2016
Pu Duann, Elias A. Lianos, Jianjie Ma, Pei-Hui Lin,

Kidney is a vital organ with high energy demands to actively maintain plasma hemodynamics, electrolytes and water homeostasis. Among the nephron segments, the renal tubular epithelium is endowed with high mitochondria density for their function in active transport. Acute kidney injury (AKI) is an important clinical syndrome and a global public health issue with high mortality rate and socioecon...

Journal: :The journal of the Royal College of Physicians of Edinburgh 2013
S Reuter, R Mrowka,

Acute kidney injury (AKI) represents a medical emergency associated with poor clinical outcomes. The international guideline group Kidney Disease: Improving Global Outcomes (KDIGO) has defined AKI according to rises in serum creatinine and/or reductions in urine output. Any patient who meets the criteria for AKI should be reviewed to ascertain the cause of AKI and the severity of the injury sho...

Journal: :Clinical medicine 2009
Andrew S Levey, Matthew T James,

Acute kidney injury is a heterogeneous group of conditions characterized by a sudden decrease in glomerular filtration rate, manifested by an increase in serum creatinine concentration or oliguria, and classified by stage and cause. This type of injury occurs in approximately 20% of hospitalized patients, with major complications including volume overload, electrolyte disorders, uremic complica...