objective(s): renal ischemia reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal ir. the purpose of this study was to investigate the effect of co-administration of melatonin (mel) and erythropoietin (epo), potent antioxidant and an...

PURPOSE Warm hepatic ischemia-reperfusion (I/R) injury can lead to multiorgan dysfunction. The aim of the present study was to investigate whether acute liver I/R does affect the function and/or structure of remote organs such as lung, kidney, and heart via modulation of extracellular matrix remodelling. METHODS Male Sprague-Dawley rats were subjected to 30 min partial hepatic ischemia by cla...

background: acute kidney injury (aki) is a common problem in critically ill patients and is independently associated with increased morbidity and mortality. recently, serum cystatin c has been shown to be superior to creatinine in early detection of renal function impairment. we compared estimated gfr based on serum cystatin c with estimated gfr based on serum creatinine for early detection of ...

background: hair dye poisoning, with main toxic component paraphenylene diamine, is a medical emergency. it is on increasing trend in developing countries due to wide availability and low cost of hair dyes. it carries a high mortality and does not have any specific antidote. case report:  twenty three years old patient presented with breathelessness along with difficulty in speaking for one hou...

conclusions aki is common in urology patients. the underlying aetiologies of aki in this group may explain a lower overall mortality, although increasing aki severity remains a marker of patients at higher risk of poor outcomes. the low rate of renal recovery suggests that urology patients who sustain aki are exposed to a significant risk of ckd and its attendant consequences for long term heal...

background exertional heat stroke (ehs) is still a main cause of death in sport. many of ehs complications could have been prevented if ehs had been recognized and treated early and properly. case presentation we report an unusual case of multiple organ failure caused by ehs due to intensive sportive activities in a hot environment with lack of primary care. a 35-year-old healthy sportive man w...

results there were no significant differences between the 4 groups in white blood cell count, hemoglobin, hematocrit, and esr at baseline (p > 0.05). the number of platelet units was remarkably higher, but the number of mpv and hco3 was considerably lower in patients with loss/ failure criteria. conclusions mpv is higher in the case of platelets destruction, and this is commonly observed in inf...

background: wasp stings are quite commonly observed in bangladesh though they are under reported. however, rhabdomyolysis following multiple wasp stings is a rare entity. case report: a middle aged physician was stung by a swarm of wasps at multiple sites of the body. he felt severe pain at the sites of the stings and was primarily treated with intravenous hydrocortisone and chlorpheniramine. w...

We investigated the effect of erythropoietin (EPO) on differentiation and secretion of bone marrow-derived mesenchymal stem cells in an acute kidney injury microenvironment. Acute kidney injury mouse models were prepared. Both renal cortices were then immediately collected to produce the ischemia/reperfusion kidney homogenate supernatant. The morphological and ultrastructural changes in the cel...

dendrobium genus was reported to contain alkaloid, bibenzyl, fluorenone, phenanthrene, sesquiterpenoid, and phenolic acid, which have biological properties. our aim was to investigate the protective effect of an aqueous extract of dendrobium nobile lindl (dne) against cisplatin-induced acute kidney injury (aki). quantification of four phenolic acids (4-hydroxybenzoic, vanillic, syringic, and fe...