Abstract Adipogenesis of intramuscular fat tissue in ruminant animals occurs from late pregnancy to first months age. Therefore, the potential (IMF) deposition lasts fetal phase until weaning. This crucial period is known as marbling window. Marbling stablished by both hyperplasia and hypertrophy processes, this attribute can be modulated a strategic nutrient plan or bioactive compounds. Some s...

Background: High amidoxime reductase activity is found in liver and fat tissue, although its composition in cells is unknown. Results: Amidoxime reductase is upregulated during adipogenesis and requires MOSC2 and CYB5B. Conclusion: MOSC2 and CYB5B are essential components of the mitochondrial amidoxime reductase and MOSC2 is important for lipogenesis. Significance: We suggest a role of MOSC2 in...

Ginseng is a traditional medicine with health benefits for humans. Protopanaxadiol (PPD) an important bioactive compound found in ginseng. Transgenic rice containing PPD has been generated previously. In the present study, extracts of this transgenic were evaluated to assess their antiadipogenic and anti-inflammatory activities. During adipogenesis, cells treated seed extracts. The results reve...

Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes involved in adipogenesis and/or lipid storage. To provide a systematic analysis of genes that regulate adipose tissue biology and to establish...

BACKGROUND/OBJECTIVES Increased mass of adipose tissue in obese persons is caused by excessive adipogenesis, which is elaborately controlled by an array of transcription factors. Inhibition of adipogenesis by diverse plant-derived substances has been explored. The aim of the current study was to examine the effects of the aqueous methanol extract of laver (Porphyra yezoensis) on adipogenesis an...

Adipogenesis involves a complex signaling network requiring strict temporal and spatial organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, facilitate such organization, and we have previously identified 14-3-3ζ as an essential scaffold in adipocyte differentiation. The interactome of 14-3-3ζ is large and diverse, and it is possible that novel adipogenic factors ma...

Fat-specific protein 27 (FSP27)/CIDEC was initially identified by its upregulation in TA1 adipogenesis and is one of three cell death-inducing DFF45-like effector (CIDE) family proapoptotic proteins. Ectopic expression of CIDEs promotes apoptosis of mammalian cells. On the other hand, FSP27 has very recently been illustrated to regulate lipid droplet size and promote lipid storage in adipocytes...

Insulin is a potent adipogenic hormone that triggers an induction of a series of transcription factors governing differentiation of pre-adipocytes into mature adipocytes. However, the exact link between the insulin signaling cascade and the intrinsic cascade of adipogenesis remains incompletely understood. Herein we demonstrate that inhibition of prenylation of p21ras and Rho-A arrests insulin-...