نتایج جستجو برای Animal model

تعداد نتایج: 1459170  

Skeletal muscle injuries are one of the most common problems in the worldwide which impose a substantial financial burden to the health care system.  Accordingly, it widely accepted that muscle regeneration is a promising approach that can be used to treat muscle injury patients. However, the underlying mechanisms of muscle regeneration have yet to be elucidated. The muscle structure and muscle...

2012
Tsuyoshi Shimamura, Nobuo Kubota, Kazutoshi Shibuya,

Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host's normal immune function. Many scientists have attempted to establish an experimental animal model to elucidate the pathogenesis of human dermatoph...

2012
Hyun Ah Kim, Eun Jeong Cheon,

Osteoarthritis (OA) is the most common arthritis which leads to chronic disability. Because patients usually present at medical care at an advanced stage of disease, research on pathogenesis of OA using human subjects is difficult. Therefore, animal models of OA are used extensively in search of pathogenesis of degenerative joint disease and in search of potential disease modifying anti-OA drug...

Introduction: Response to morphine and role of Nitric Oxide (NO) on expression of morphine response has been studied in vertebrates. But, little evidence is provided in the matter in earlier invertebrates. This investigation for the first time evaluated the effect of NO on expression of morphine potency in Paramecium caudatum. Methods: Animal after isolation from natural media and specific i...

2005

The discussion starts out with three examples of relationship matrices and their corresponding inverses. This illustrates two points: 1) any complete relationship inverse can be formed from the inverse of the relationships among parents; and 2) the only non-zero elements in the relationship inverse are between parents, parents and progeny, and between mates. Three equivalent models are develope...

F ALASTI, MH SANATI,

To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...

2013
Nandini Dey, Yuliang Sun, Brian Leyland-Jones, Pradip De,

Patient derived xenograft (PDX) is defined as a growth of patients’ tumor in the xenograft setting. The evolution of cancer model in animal has a century old history. The most single reason that exerted the pressure on the traditional animal model of cancer to evolve to PDX is that the traditional models have not delivered as expected and traditional models have not predicted clinical success. ...

2016

Keloids and hypertrophic scars are basically an overabundance of fibrosis in cutaneous healing process. Unfortunately, keloids are only found in human beings. So far no successful animal model of keloid has been reported. Objectives: To produce an animal model of keloid. Main Outcome Measure: Animal model of keloid. Design: Prospective quasiexperimental trial. Setting: Department of Pathology a...

Journal: :Drug discoveries & therapeutics 2012
N Sekimizu, A Paudel, H Hamamoto,

Sacrificing model animals is required for developing effective drugs before being used in human beings. In Japan today, at least 4,210,000 mice and other mammals are sacrificed to a total of 6,140,000 per year for the purpose of medical studies. All the animals treated in Japan, including test animals, are managed under control of "Act on Welfare and Management of Animals". Under the principle ...

2009
Bennet Cassell,

Virginia Cooperative Extension programs and employment are open to all, regardless of race, color, national origin, sex, religion, age, disability, political beliefs, sexual orientation, or marital or family status. An equal opportunity/affirmative action employer. Issued in furtherance of Cooperative Extension work, Virginia Polytechnic Institute and State University, Virginia State University...

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