Cells generate unpaired electrons, typically via oxygen- or nitrogen-based by-products during normal cellular respiration and under stressed situations. These pro-oxidant molecules are highly unstable and may oxidize surrounding cellular macromolecules. Under normal conditions, the reactive oxygen or nitrogen species can be beneficial to cell survival and function by destroying and degrading pa...

Purpose of review The role of antioxidants in the management of hearing loss has generated considerable interest over the past several years. Research efforts in this field have yielded many new insights into the molecular and cellular nature of several types of hearing impairment, including age-related, noiseinduced, and drug-induced hearing loss. The objective of this paper is to highlight so...

Introduction: Hydrogen peroxide (H2O2) is a biologically important, non-radical reactive oxygen species (ROS) that can influence several cellular processes. Ability of anti-oxidants to scavenge H2O2 can be measured by several methods but all the methods are suffering from several lacunae due to poor reproducibility, lack of specificity, inaccuracy, high cost etc. Objective: The present study ai...

1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported. 2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect...

Implication for health policy/practice/research/medical education: This study helps to improve the research and practice. Copyright © 2013, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Licensee DocS Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unres...

The effectiveness of certain non-tocopherol anti-oxidants in preventing or delaying the appearance of signs of vitamin E deficiency in various species has been demonstrated. These deficiency syndromes include exudative diathesis (Dam, Kruse, Prange & Smdergaard, 195 I ) and encephalomalacia (Singsen, Bunnell, Kozeff, Matterson & Jungherr, 1955) in the chick, resorption-gestation in the rat (Dam...

Insulin resistance and abdominal obesity are present in the majority of people with the metabolic syndrome. Antioxidant therapy might be a useful strategy for type 2 diabetes and other insulin-resistant states. The combination of vitamin C (Vc) and vitamin E has synthetic scavenging effect on free radicals and inhibition effect on lipid peroxidation. However, there are few studies about how to ...