delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...

rheum turkestanicum janischew. (polygonaceae) is a plant that grows in central asia and in north-east of iran. traditionally, people use roots of r. turkestanicum as an anti-diabetic and anti-hypertensive as well as anticancer agent. in this study the cytotoxicity and apoptogenic properties of ethyl acetate (etoac), n-hexane and h2o extracts from rheum turkestanicum janischew. (polygonaceae) ro...

objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

lung exposure to sulfur mustard (sm) results in pulmonary complications, which is the main cause of long-term disability and morbidity. up to now, the precise mechanisms of sm-induced lung complications has not been identified. the aim of this study was to evaluate apoptosis in the lung tissue of sm-exposed individuals. the study was performed on archived lung paraffin-embedded tissue specimens...

introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...

Background: Oocyte cryopreservation is one of the most important topics in the field of assisted reproductive technology to preserve women fertility, but relationship between cryopreservation and apoptosis is still a matter of debate. The present study was aimed to investigate the effects of vitrification on apoptosis in mouse oocytes by Cryotop method. Method: A total of 200 germinal vesicle (...

Apoptosis is the natural programmed cell death process, which responsible for abnormal clearance. However, many cancer cells develop various mechanisms to escape apoptosis through interrupting apoptosome assembly, a key step initiate apoptosis. This promotes tumorigenesis and drug resistance, thus, poses great challenge in treatment. Herein, biomimetic lipid nanocarrier mimicking mitochondrial ...

Background: Rosmarinic acid (RA) is a natural phenolic compound that acts as Fyn inhibitor by 53 homology modeling of the human structure. Therefore, apoptosis mechanism related to NF-κB signaling pathway induced RA in HepG2 was investigated. Methods: The cell growth, apoptosis, and proliferation regulated various concentrations were studied. proteins expression MMP-2, MMP-9, PI3K, AKT, NF-κB, ...


 Purpose: To determine the antitumor effect of demethoxycurcumin on lung cancer cells, as well its PI3K/AKT/m-TOR signalling, cellular apoptosis, cell migration and invasion.
 Methods: Cell viability was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, while AO/EB annexin V/PI staining assays were used for apoptosis analysis in demethoxycurc...

Introduction Afatinib exhibits a tumor-inhibiting effect in different cancers by inducing apoptosis; however, its pro-apoptosis role glioma cells is still not fully understood. Material and methods In the current study, two cell lines (U373-MG U87-MG) were treated with afatinib to measure their tolerance for afatinib-triggered death apoptosis. Results We found that treatment repressed both grow...