background and objectives: achillea is an ancient medicinal herb. the genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. there are also several reports in iranian traditional medicine (itm) texts about its anti-tumor effect. the cytotoxic activity of the methanol extract of achillea vermicula...

To explore the potential mechanism of nobiletin in improving sensitivity breast cancer MDA-MB-231 cells to Pirarubicin. were randomly divided into Control group, Nobiletin Pirarubicin group and co-Pirarubicin group. CCK-8 assay was used detect inhibitory effect on proliferation cells, cell cycle apoptosis detected by flow cytometry. The combined with migration repair ability scratch test. Weste...

Cell autophagy and apoptosis processes are of interest in drug development contribute to the chemotherapy outcomes patients receiving cancer treatment. The functional roles cyclic nucleotides cells include maintenance metabolic homeostasis. cGMP steroid compounds participate apoptotic autophagic events, modulate function multi-drug resistance proteins. Endogenous nucleotide ratios change with a...

Characteristics of programmed cell death are generally regarded as defined by outgrowth or cellular aging and distinct morphological characteristics featuring nuclear condensation formation apoptotic bodies. Apoptosis is considered to have a function at level essential long-lived differentiation undergoing senescence apoptosis. Inappropriate apoptosis factor that results in serious conditions, ...

abstractferulago angulata boiss. known in iran as chavir, has some bioactive compounds having antioxidant activity. because of its antioxidant activities, it sounded chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. in this study, the cytotoxic effects and proapoptotic activities of chavir’s leaf and flower extracts ...

objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...

objective(s):one cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. it has been shown that chinese green tea (cgt) (lung chen tea) has higher antioxidant property than black tea. in this paper, we will explore the preventive effect of cgt on cigarette smoke-in...

background: interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. alternative treatments with herbal extracts offer insights into acute myeloid leukemia (aml) therapy. parthenolide (ptl), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (lscs) and bulk leukemic cell popul...

Background: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabolic sensor, could be activated with metformin and it can also launch a p53-dependent metabolic ch...