introduction: cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. the purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. methods: to induce bilateral cryptorchid model, immature mice were anesthetized and a...

lead (pb), has, for decades, being known for its adverse effects on various body organs and systems. in the present study, the damage of pb on the liver tissue apoptosis was investigated, and lycopersicon esculentum as an antioxidants source was administered orally to prevent the adverse effects of pb. eighteen wistar rats, randomized into three groups (n=6), were used for this study. animals i...

introduction : arsenic trioxide (as2o3) causes antitumor effects by various mechanisms, including degradation of pml-rara in the acute promyelocytic cells, growth inhibition and induction of apoptosis. however, the precise mechanisms of these processes remain incompletely understood. the purpose of this study was to evaluate the effects of arsenic trioxide on cell growth, cell cycle regulation ...

background and objective: as one of the widely used drugs, aspirin (acetyl-salicylic acid, asa) plays an important role in stroke treatment and prevention. in a previous study, we demonstrated asa injection at 30 min after ischemia onset is neuroprotective. to determine whether the neurons protected by asa had a normal ultrastructure, hippocampal ca1 pyramidal neurons were examined by transmiss...

background: deltamethrin (dm) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. there is accumulating evidence that oleuropein (oe) has anti-apoptotic effect. this study aimed at determining the dm toxicity and anti-apoptotic effect of oe pretreatment in cerebellar purkinje neurons. materials and methods: rats were randomly divided into four groups as f...

conclusions in general, it seems that three-month exercise training was effective in reducing cardiac mitochondrial pro-apoptotic protein. however, considering the results of the bcl2 gene expression, more researches are needed to identify effects of exercise trainings on indices of myocardial apoptosis. objectives the aim of this study was to assess the effect of exercise training on bcl-2 and...

Apoptosis, programmed cell death, has a central role in developmental biology and maintaining the equilibrium of renewing tissues. A founding member Bcl-2 family regulatory proteins for apoptosis is Bcl-2, which encoded by BCL2 gene. Caspase-3 shares typical features with all caspases, including acting as crucial mediator apoptosis.

apoptosis, a form of programmed cell death that occurs under physiological as well as pathological conditions, is characterized by morphological and biochemical features. while the importance of caspases in apoptosis is established, several noncaspase proteases (ca2+-dependent proteases) such as calpain may play a role in the execution of apoptosis. the calpain family consists of two major isof...

fasting, that is usually described as abstinence from all food and drink for a period of time, has been experienced for ages. health, protest, religious expressions of devotion and purification are the most important reasons for fasting. many changes occur in the body during fasting including metabolic, mineral, hormonal, immunological and psychological. its use as one of the oldest therapies a...