A subset of CD4+CD11c-CD3- blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4+ CD11c-CD3- cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers ...

Abstract Dendritic cells (DCs) are disseminated throughout organisms and serve as sentinels, organizing immune responses to infection, tissue damage, cancer. DCs play a crucial role bridging innate adaptive systems elicit tailored response the types of threats they encounter. Manipulation is critical for vaccination, DC-based immunotherapies have been tested in clinical trials anti-cancer thera...

Abstract Cerebral malaria (CM) is a severe complication of P. falciparum infection and leading cause death, globally. Plasmodium berghei ANKA (PbA) C57BL/6 mice serves as murine model CM called experimental cerebral (ECM) due to the neurological neuropathological features that simulate human CM. A putative mechanism disease in requires CD8 T cell infiltration into brain blood-brain barrier disr...

INTRODUCTION Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying patients as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In rheumatoid arthritis (RA), t...

Lung CD11c(high) dendritic cells (DC) are comprised of two major phenotypically distinct populations, the CD11b(high) DC and the integrin alpha(E)beta(7)(+) DC (CD103(+) DC). To examine whether they are functionally distinguishable, global microarray studies and real-time PCR analysis were performed. Significant differences between the two major CD11c(high) DC types in chemokine mRNA expression...