The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 ...

this study presents the first ever data of extracting chitin from the chiton shell, which then converted to the soluble chitosan by soaking in the 45% naoh solution. the obtained chitin and chitosan were characterized by the seven different methods. antioxidant activity of the extracted chitosan was also evaluated using the two methods. the shell content was divided into calcium carbonate (90.5...

background: chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. the aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

background: curcumin as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. one of the nanoparticles ability is to decrease the defects of usual drug delivery systems. chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of nanoparticles. nanoparticles like chitosan-tripolyphosphate (tpp) are able to increas...

Chitosan is a naturally occurring polysaccharide with antimicrobial properties. This study investigated whether chitosan could induce the LytSR two-component autolytic regulatory system, specifically the cid and lrg operons, found in Streptococcus mutans. A turbidity assay and a murein hydrolase assay were used to observe autolytic activity in chitosan-treated and non-treated cultures of wildty...

A conjugate from the YIGSR peptide and chitosan has been prepared on the basis of a regioselective modification strategy of chitosan, and its antimetastatic activity has been assayed. Chitosan was converted to its organosoluble derivative, 6-O-trityl-chitosan, in 3 steps, and then coupled with the peptide portion containing a spacer amino acid, Ac-Tyr-Ile-Gly-Ser-Arg-beta Ala-OH [beta Ala; beta...

The depolymerization of chitosan by plasma in the presence of hydrogen peroxide (H(2)O(2)) was investigated. The efficiency of the depolymerization was demonstrated by means of determination of viscosity-average molecular weight and gel permeation chromatography (GPC). The structure of the depolymerized chitosan was characterized by Fourier-transform infrared spectra (FT-IR), ultraviolet spectr...

A study was conducted to evaluate the effects of chitosan on enteric methane (CH4) and total tract nutrient digestibility of beef heifers consuming either a high-concentrate (HC; 85% concentrate) or a low-concentrate (LC; 36% concentrate) diet. Heifers were provided their respective diets ad libitum along with one of three dietary inclusion rates of chitosan: 1) CTRL=0.0% of chitosan in the die...

Both chitosan and polylactide/polyglycolide have good biocompatibility and can be used to produce tissue engineering scaffolds for cultured cells. However the synthetic scaffolds lack groups that would facilitate their modification, whereas chitosan has extensive active amide and hydroxyl groups which would allow it to be subsequently modified for the attachment of peptides, proteins and drugs....

Chitosan was evaluated for its potential to induce antifungal hydrolases in susceptible turmeric plant (Curcuma longa L.). Under field conditions, the application of chitosan (crab shell) to turmeric plants by foliar spray method induces defense enzymes such as chitinases and chitosanases. Such an increase in enzyme activity was enhanced by spraying chitosan (0.1% w/v) on leaves of turmeric pla...