Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled ...

context biocompatible polymers are potentially effective for dental infections as delivery carriers of disinfectants or antibiotics into the root canal system (rcs). this study aimed to review polymeric microspheres enabling a controlled release of endodontic medicaments. evidence acquisition a literature search was carried out in the pubmed database (may 2013) using the following keywords: “po...

Controlled drug delivery occurs when a polymer is combined with a drug in a such a way that the release profile is predefined. Conventional forms of drug delivery are based on tablets, eye drops, ointments and intravenous solutions. These delivery systems were characterized by an immediate and non controlled kinetics depending essentially on the properties of tissues to absorb drugs.In the last...

Three chitosan (CS), polyethylene glycol (PEG) and polylactic acid (PLA) nanocomposite systems containing SiO2 nanoparticles and water molecules were designed by molecular dynamics (MD) simulations to deliver pipobromane (PIP) anticancer drug in order to discover the most appropriate drug delivery system (DDS) in aqueous medium which was analogous to the human body. The density for the CS matri...

INTRODUCTION Oral controlled release dosage forms have been developed over the past three decades due to their considerable therapeutic advantages such as ease of administration, patient compliance and flexibility in formulation. The controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the d...

This review seeks to give an overview of the current approaches to drug delivery from scaffolds for neural tissue engineering applications. The challenges presented by attempting to replicate the three types of nervous tissue (brain, spinal cord, and peripheral nerve) are summarized. Potential scaffold materials (both synthetic and natural) and target drugs are discussed with the benefits and d...

The immediate release conventional dosage form lack in the efficiency of controlling the proper plasma drug concentration. This results in the development of various controlled drug delivery system. Among which the Pulsatile drug delivery systems (PDDS)/ osmotic drug delivery system (ODDS) are gaining importance as these systems deliver the drug at specific time as per the path physiological ne...

Drug delivery systems, particularly nanomaterial-based drug delivery systems, possess a tremendous amount of potential to improve diagnostic and therapeutic effects of drugs. Controlled drug delivery targeted to a specific disease is designed to significantly improve the pharmaceutical effects of drugs and reduce their side effects. Unfortunately, only a few targeted drug delivery systems can a...

      The objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (DDS) for Metoprolol tartarate (MT) as tablet and capsule. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal del...

There has been keen interest in the development of a novel drug delivery system. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. At present, no available drug delivery system behaves ideally achieving all the lofty goals, but sincere attempts have been made to ach...