Drug delivery systems (DDS) have extensively progressed over the past decades for eradicating bacteria embedded in biofilms while minimizing side effects of antimicrobials on normal tissues. They possess potential solving challenges intrinsic antimicrobial-resistance and poor penetration into biofilms. However, guidelines developing a controlled DDS combating bacterial are limited. In this revi...

Over the past 30 years as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. Bilayer tablet is new era for the successful development of controlled release formulatio...

Cationic polymeric nanoparticles have great potential for developing drug delivery systemswith limited side effects for tumor medication. The goal of this research is investigation ofcationic dextran-spermine polymer (DS) efficacy for improvement of hydrophilic drug deliveryto negatively charged cancerous cells. Capecitabine (as a hydrophilic antineoplastic drug) wasloaded into the magnetic dex...

In this paper we review the mathematical models used to determine the kinetics of drug release from drug delivery systems. The quantitative analysis of the values obtained in dissolution/release rates is easier when mathematical formulae are used to describe the process. The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the effi...

Therapeutic drugs administered systematically are evenly distributed to the whole body through blood circulation and have to cross many biological barriers before reaching the pathological site. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the urinary system resulting in suboptimal...

Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery. Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of optim...

objective(s): nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. temperature and ph-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or ph. the objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer...