This paper investigates the mechanism of water transportation through aquaporin-4(AQP4) of ratbrain cells by means of molecular dynamics simulation with CHARMM software. The AQP4 wasembedded into a bilayer made of Dimystroilphosphatylcholine (DMPC). The results illustrate thatwater molecules move through AQP4's channel with change of orientation of oxygen of eachwater molecule.

We investigated molecular motions on a picosecond timescale of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) model membranes as a function of hydration by using elastic and quasielastic neutron scattering. Two different hydrations corresponding to approximately nine and twelve water molecules per lipid were studied, the latter being the fully hydrated state. In our study, we focused on hea...

Helix 7 in the Cry4Ba-pore-forming domain contains conserved Tyr(249) and Phe(264) that are crucially involved in mosquito-larvicidal activity. We have now characterized lipid-induced conformation of a 27-residue Cry4Ba-alpha7 peptide in phospholipid membranes using ATR-FTIR and hydrogen/deuterium (H(+)/D(+)) exchange experiments. ATR-FTIR results showed that conformation of this peptide is inf...

The limited solubility of cholesteryl esters in polar lipids is important as it determines their access to polar surfaces of lipoproteins, their interaction with plasma membranes and their phase formation with phospholipids. Variations in cholesteryl ester concentrations in membranes may be related to the physiological role of the membranes. In lysosoma1 membranes cholesteryl ester concentratio...

in this work we sought to determine whether vesicles (liposomes/niosomes) were able to enhance finasteride concentration in the dermis layer, including the pilosebaceous units (psu). such enhancement could be beneficial in the treatment of some androgen-related skin disorders. hamster flank skin was used to study  3hfinasteride permeation via vesicles and a hydroalcoholic solution (ha). the dru...